Are you willing to share what you're anxiety is about? I had panic and anxiety attacks for years and used Ativan and later Lorazepam for them, especially when I had to fly in planes. About 6 years ago I started taking Citalopram antidepressant, and all my anxiety/panic attacks went away. I only had it again recently during my withdrawal process. I know my relief from anxiety is from the Citalopram. I even did 7 zip lines in Costa Rica a little over a year ago. My flights there, to Panama and back were anxiety free. That has been so incredible for me! I love traveling now.
So far, though, there’s scant clinical evidence for the claimed benefits of CBD. In June, the Food and Drug Administration approved the first CBD drug, Epidiolex, for treating seizures associated with two rare forms of epilepsy. Otherwise, the FDA doesn’t consider CBD products to be dietary supplements—manufacturers can’t claim the products will diagnose, treat, or cure any diseases. Instead, CBD product literature contains phrases like “restore vitality,” “relax and recover,” and “may keep healthy people healthy.”
Hi, I had ovarian cancer stage 2 and went to do chemotherapy for 16 times in 2014. It came back last year 2016 but I did not do chemotherapy or radiation therapy as suggested by the doctor. I am taking hormone therapy at the moment. I would like to use cannabis oil but which one and how much CBD and how much THC should I take for ovarian cancer? Can anyone give some idea?. Thank you very much.
Worsening of anxiety: Though most research indicates that cannabidiol is likely to decrease anxiety in humans and animal models, contrasting evidence necessitates consideration. A study published in 2012 by ElBatsh et al. examined the effects of CBD administration on rodent behavior and protein expression.  Notably, CBD decreased frontal and hippocampal BDNF and reduced TrkB and phosphor-ERK1/2 expression.  This suggests that when used frequently, CBD may exacerbate underlying anxiety. (Source: https://www.ncbi.nlm.nih.gov/pubmed/22083592).
Yes, CBD oil can be used in anxiety. It has been found that CBD can even be a very effective remedy for it. At least that’s what a lot of users report about CBD. But there are already some scientific studies which can confirm this statement, which we will look at in more detail on this page below. Also, there are countless reports from people who use CBD for anxiety with sometimes amazing results. Which can also be found on our site Reviews & Testimonials.
Enter CBD oil: an anti-inflammatory and anti-anxiety compound. I have seen in my own life, and many of my patients' lives, the positive impact CBD oil can have on anxiety. Studies have found that CBD oil is a natural anxiolytic (anxiety calmer) and is effective in treating social anxiety. CBD calms anxiety naturally without the potential side effects of pharmaceutical anti-anxiety medications.
Given what you know about CBD already, you likely won’t be surprised to learn that it does not work like typical sleep medications do. In fact, some studies have shown it to actually be mildly alerting, and even to activate some of the same receptors that caffeine does. With this in mind, how can it possibly work to promote a healthy night’s sleep?
Cannabidiol (CBD), one of the major compounds of Cannabis sativa, has been shown to have several therapeutic effects including antipsychotic (Zuardi et al., 1991; Leweke et al., 2000; Moreira et al., 2006), antidepressant (Zanelati et al., 2010), anti-epileptic (Devinsky et al., 2016) anti-inflammatory (Esposito et al., 2013), and analgesic properties (Boychuk et al., 2015), besides improving Parkinson’s disease symptoms (Chagas et al., 2014c).
The vape would be very easy to carry around, but I don’t really enjoy having to inhale something, as it reminds me of when I had a problem with drugs back in the day.  You’d also have to use it more often.  This could be a great method for you, however, the brand I used was probably low quality and I have no idea if using a better brand would change my opinion on using a vape.
Likewise, selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) may interfere with sleep architecture and decrease restorative sleep, leading to increased awakenings, reduced REM sleep, increased REM latency, as well as increased periodic limb movement during sleep (Feige et al., 2002). In addition, SSRIs and SNRIs have been associated with REM sleep without atonia, characterized by increased tonic or phasic motor activity in electromyographic channels during REM sleep (Schenck et al., 1992; American Academy of Sleep Medicine, 2014; Lee et al., 2016).
CBD Essence company unquestionably understands some facts about hemp oil. The proprietor Don has genuinely been around the pharmaceutical business for many years, and subsequently, he knows how to convey a quality and successful item. Every one of their oils is made utilizing CO2 extraction techniques. They maintain a strategic distance from CBD isolates, and they generally uncover lab test results to guarantee there is no substantial metals or contaminants in the oil.
Even as the research proceeds, thousands of people are using CBD as medicine. A British pharmaceutical company, GW Pharma, has developed two CBD drugs: Sativex, which contains a 1-to-1 ratio of CBD and THC, and Epidiolex, which is pure CBD. The former is prescribed for the painful muscle spasms that occur in multiple sclerosis, while the latter is aimed at childhood seizures. Sativex is not available in the United States, but it is approved in 29 other countries, including Canada, England and Israel.
Results from the study indicated that CBD administration increased neuronal proliferation and neurogenesis in the hippocampal region.  It is also thought that CBD’s modest affinity for cannabinoid receptors CB1 and CB2 may contribute to hippocampal neurogenesis.  Stimulation of the CB1/CB2 receptor sites upregulates endocannabinoid signaling and leads to neuronal growth.

Cost: For high quality, unadulterated CBD – you’re going to pay a hefty price. Assuming you don’t want a product with pesticides, herbicides, fertilizers, and/or other chemical additives, you’ll likely end up paying a significant amount for just a few doses.  Until scientists figure out a way to enhance CBD’s bioavailability, regular users of oral CBD may feel as if the supplement is too costly.  Fortunately, there are other ways to administer cannabidiol such as vaporizing the oil – which will likely save consumers money.
Elias Anderson, one of the owners of Going Green, said representatives from HempMedsPx approached him after Krenzler published the lab’s findings on his blog. “They were like, ‘What are we gonna do about it?’” Anderson recalled, “And I was like, ‘Nothing. We have standards, and I stand behind my test results.’” Still, the company’s representatives were insistent and advised Anderson to have Kenzler take down the lab’s findings. In an email to the New Republic, Hard, the Medical Marijuana, Inc. spokesman, contended that the sample of hemp oil that Going Green Labs tested had been “tampered with” by a competitor after Krenzler obtained it. “HempMedsPX, if anything, told the lab they cannot publish results from products [for which] they had no chain of custody tracked,” Hard said, “and if they did—that could prove to be very bad for the lab.” He also characterized Krenzler and Anderson as “haters” of Medical Marijuana, Inc., and suggested that much of the criticism of the company and its products comes from commercial competitors.
Summary: Early research has found that CBD oil has the potential to reduce chronic pain, anxiety, depression and acne, and may help those overcoming addiction. Its anti-inflammatory properties may also play a role in lowering the risk of diabetes and cardiovascular disease. It has even shown anti-tumor effects and could be effective in inhibiting the progression of cancer and its related symptoms.
I didn’t use the oil again until maybe about a week later, and I tried the next time around to really gauge when the effects started settling in. I was using the 300 mg bottle (30 mL), which I think is their lowest potency oil (they also had a 600 mg oil and a 1000 mg oil the last time I checked). It seemed to me that I noticed an obvious anxiety relief in less than an hour – maybe about 45 minutes, if I had to take a guess.
Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects. CBD’s anxiolytic actions appear to depend upon CB1Rs and 5-HT1ARs in several brain regions; however, investigation of additional receptor actions may reveal further mechanisms. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. Current preclinical and human findings mostly involve acute CBD dosing in healthy subjects, so further studies are required to establish whether chronic dosing of CBD has similar effects in relevant clinical populations. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders.
About one in ten Americans suffer from restless leg syndrome (RLS). This disorder is characterized by an overwhelming urge to move ones legs while at rest or trying to sleep. These urges are often unpleasant and can cause great discomfort and of course a lack of sleep. The cause of RLS is still unknown, but research suggests that it can be related to abnormalities in the central nervous system.
That’s precisely why I was intrigued when I started hearing about CBD, or cannabidiol, a nonpsychoactive compound found in the cannabis or hemp plant that apparently helps with sleep and anxiety. I didn’t exactly get my hopes up ― after all, tons of natural remedies that worked for other people hadn’t worked for me ― but I figured it was worth a shot.
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Possession or manufacture of cannabis and cannabis extracts is illegal in most jurisdictions. People caught with small amounts of extracts can face extremely harsh prison sentences. As of 2017 in some regions of the United States mandatory minimums of a year in jail still exist. However, it is widely produced in states where cannabis has been legalized.[1]
It's the Wild West out there. Without any federal regulatory body checking labels, consumers have very little way of knowing what they're buying when they purchase CBD oil. Bonn-Miller co-authored a study that found that 26 percent of CBD products on the market contained less CBD than their label claimed. So the amount you need for an effective dose could vary drastically, not just from product to product, but from bottle to bottle of the same product.
I suffer fr migraines. Currently having Botox injections every three months for the last three years. This has helped went fr 24 to 30 migraines a month to 6 to 8 , now I'm back up to 14 to 20 a month. My doctor thought CBD oil might help. I have also started having anxiety attacks for a year now. I'm really confused with the dosages. Any thoughts would b helpful
Vaping can be complicated, intimidating, and expensive, but with this brilliant Disposable Vape Pen with CBD from CBDfx, you can start vaping with ease. It comes pre-charged and pre-filled with a refreshing, minty e-liquid and has been designed with simplicity at its heart. Simply remove from the packaging and start vaping. Once you’re finished, throw it away!
There's plenty of anecdotal evidence that CBD helps treat a variety of ailments. People are turning to oils, gummies, and other CBD food and drink products to relax at the end of a long day. Retired NFL players are using CBD to manage physical pain, debilitating headaches, and sleeplessness. Spa clients are even using CBD skin products to fight signs of aging.
In June 2018, following the FDA approval of Epidiolex for rare types of childhood epilepsy, Epidiolex was rescheduled as a Schedule V drug allowing its legal use as a pharmaceutical drug.[11] This change applies only to FDA-approved products containing no more than 0.1 percent THC.[63] This allows GW Pharma to sell Epidiolex, but it does not apply broadly and all other CBD-containing products remain Schedule I drugs.[63]

How do you know if you're having a panic or anxiety attack? Panic attacks and anxiety attacks share some symptoms, but they differ in intensity, duration, and whether or not there is a trigger. Some treatments are similar and include therapy, stress management, and breathing exercises. Learn more about the differences between a panic attack and an anxiety attack here. Read now
Elias Anderson, one of the owners of Going Green, said representatives from HempMedsPx approached him after Krenzler published the lab’s findings on his blog. “They were like, ‘What are we gonna do about it?’” Anderson recalled, “And I was like, ‘Nothing. We have standards, and I stand behind my test results.’” Still, the company’s representatives were insistent and advised Anderson to have Kenzler take down the lab’s findings. In an email to the New Republic, Hard, the Medical Marijuana, Inc. spokesman, contended that the sample of hemp oil that Going Green Labs tested had been “tampered with” by a competitor after Krenzler obtained it. “HempMedsPX, if anything, told the lab they cannot publish results from products [for which] they had no chain of custody tracked,” Hard said, “and if they did—that could prove to be very bad for the lab.” He also characterized Krenzler and Anderson as “haters” of Medical Marijuana, Inc., and suggested that much of the criticism of the company and its products comes from commercial competitors.
A 2013 case report conducted in Canada evaluated the beneficial effects of cannabis oil on a 14-year-old female patient diagnosed with acute lymphoblastic leukemia, also known as ALL. For this particular patient, a standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. She was extremely ill and severely underweight at this time.
Mood enhancement: While CBD isn’t known for provoking a euphoric high, there’s some evidence to suggest that it may enhance mood. Research in animal models notes that CBD yields a combination of anxiolytic and antidepressant effects.  That said, this research cannot be generalize to humans.  If you’re severely depressed, don’t expect CBD to treat your depression.  However, the fact that the drug targets the 5-HT1A receptor and CB1/CB2 receptors suggests that it could improve mood in certain individuals.
I will say that it was pretty awkward trying to not swallow for 90 seconds – it’s a totally unnatural feeling, and you feel like you’re going to start drooling all over yourself. You’ll have to fight the instinct to swallow just a little bit, but it’s really not that bad (also, it says on the bottle that you can hold for 60 seconds instead of the full 90 if you want to). I did take a nice big swig of cold water after I swallowed the oil, though, just to get the slightly bitter-ish vanilla flavor out of my mouth (but again, the flavor really is not bad).

Relevant studies in animal models are summarized in chronological order in Table ​Table1.1. CBD has been studied in a wide range of animal models of general anxiety, including the elevated plus maze (EPM), the Vogel-conflict test (VCT), and the elevated T maze (ETM). See Table ​Table11 for the anxiolytic effect specific to each paradigm. Initial studies of CBD in these models showed conflicting results: high (100 mg/kg) doses were ineffective, while low (10 mg/kg) doses were anxiolytic [59, 60]. When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose–response curve, with anxiolytic effects observed at moderate but not higher doses [61, 90]. All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [62, 65], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Campos et al. [66] showed that in rat, CBD treatment for 21 days attenuated inhibitory avoidance acquisition [83]. Long et al. [69] showed that, in mouse, CBD produced moderate anxiolytic effects in some paradigms, with no effects in others.
We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.
Verified CBD is a great example that you shouldn’t judge the book by its cover. Although the information about the company is scant, and the team seems to be completely okay with that, once you engage into an e-mail conversation with them, you will get answers to absolutely any question that bothers you. Besides, when a company has been successfully selling their CBD goods to 50 countries around the world, there must be something in the water.
Based on logical examinations on the subject, in 2011 a gathering of specialists directed an investigation that reformed the considerations about CBD and anxiety. They took ten individuals with social anxiety who had never had any treatment for this issue and separated them into two gatherings. One gathering was given 400mg of CBD and the other fake treatment. The outcomes demonstrated that the individuals who had gotten the CBD oil had effectively enhanced their anxiety side effects contrasted with the phony treatment.
Increased anxiety: Rodents administered cannabidiol daily for 14 days exhibited anxiogenic behaviors. In other words, the cannabidiol may increase anxiety when used too regularly.  Although this effect cannot be confirmed in humans, it is logical to assume that a person’s neurophysiology will adapt to the effects of CBD when used regularly, possibly blunting its efficacy.
For kids with severe forms of epilepsy, changes in medication levels can be extremely dangerous. “If their levels go low, they’re at increased risk of seizures, which could lead to an emergency room visit or an ICU stay,” Knupp said. “On the other hand, if their levels go high, their side effects can increase dramatically.” Side effects from epilepsy medications can range anywhere from drowsiness to vomiting to heart arrhythmia, Knupp noted. “For some people that could mean a minor inconvenience, but for some patients it could be life-threatening.”
One thing that I really really liked though, was that the effects seemed to last a long time. I have only taken the oil on four separate occasions now, and each time it’s seemed to last like 6-8 hours (or at least all evening). This makes sense too, because after doing a little reading up I found that the sublingual tinctures are much longer-lasting than CBD vape oils or e-juices.
Thanks for your interest in our products. Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can though share our top selling products in each category. Please view the links below:http://cbdoilreview.org/product/elixinol-cbd-oil-extract-x-pen-1000mg/http://cbdoilreview.org/product/endoca-hemp-oil-drops-1500mg/http://cbdoilreview.org/product/elixinol-hemp-oil-drops-regular-300mg/http://cbdoilreview.org/product/elixinol-cbd-hemp-oil-capsules-900mg/https://cbdoilreview.org/product/vape-bright-thrive-cbd-vape-cartridge-200mg/As far as dosage goes, I would recommend reading through our page on dosing. I have attached that link below. https://cbdoilreview.org/cbd-cannabidiol/cbd-dosage/Hopefully these help.
While normally I'd be slightly tripped up by little things like an overly crowded subway car or a full inbox at work, the CBD oil seems to have taken the edge off of my anxiety a bit. Rather than overthinking a sternly worded email or analyzing a social interaction, I've found it easier to recognize the irrationality of these thoughts and actually let them go (instead of ruminating on the situation). In some ways, I feel more like myself. With that said, I've still experienced some social anxiety when meeting new groups of people—I'd be interested to see what taking the full recommended dose would do.
One of the earliest researchers of CBD as an intervention for anxiety is Zuardi.  In 1982, Zuardi et al. published a paper examining the effects of cannabidiol on anxiety induced by THC.  They also wanted to elucidate whether the attenuation of THC-induced anxiety by CBD resulted from an inhibition of THC or through a distinct anxiolytic mechanism.
A study conducted by Martin-Santos et al. (2012) aimed to compare the acute effects of two notable cannabinoids: CBD (cannabidiol) and THC (tetrahydrocannabinol).  Researchers recruited 16 healthy males and set up a randomized, placebo-controlled, double-blind, cross-over trial.  The 16 participants received three consecutive single-dose agents administered 1-month apart in the following order: 10 mg THC (oral) – first month, 600 mg CBD (oral) – second month, or a placebo – third month.
You can tell that NuLeaf Naturals don’t take half measures when it comes to manufacturing their oil; its amber-gold color and clean consistency are indicative of high quality. When it comes to the effects for sleep and insomnia, NuLeaf Naturals provides fast relief from stress, pain, and anxiety – all of which contribute to sleep deprivation. It takes a couple of minutes to experience the therapeutic benefits of CBD oil, and the effects last between 1 and 5 hours, depending on the dosage.
Acute vs. Chronic: Most studies have examined the acute effects of CBD rather than effects associated with chronic, ongoing administration. It is possible that acute administration may attenuate anxiety, but chronic administration may not.  Some individuals may become tolerant to the effects of CBD when administered chronically and/or may find that it worsens their anxiety.

Canabidol™ CBD Cannabis Oil (CBD Oli)– Available in 25%,50% and 75% concentrations. Our proprietary engineering process has been developed to isolate and remove any unwanted compounds, while creating the maximum potency level of phytocannabinoids.  State-of-the-art technology is employed to ensure a full-spectrum oil, that includes both high levels of Canabidiol, Cannabinoids and terpenes. This guarantees a consistent, pure, and premium product for our customers


There are several good reasons to choose CBD over Cannabis oil and how it is made to alleviate health conditions, but none is more important than the legality. While the issue of legal recreational marijuana, medicinal marijuana, and even cannabis therapeutic substances is in flux in the U.S., there are some key points to understand. Products high in THC content – like THC or Cannabis – may be illegal in states that haven’t legalized recreational and/or medicinal marijuana. Likewise, the DEA has ruled that all products containing certain levels of THC and from the cannabis plant are illegal. However, CBD from American Hemp Oil has no amount of THC – far below the DEA’s ceiling – and are derived from hemp. Therefore, among the other many advantages, it’s perfectly legal to use CBD oil from American Hemp Oil instead of THC or other Cannabis oils.
We're on the edge of a CBD explosion. The U.S. market for CBD products is estimated to be worth $2.1 billion by 2020, up 700 percent from 2016; the World Anti-Doping Agency removed CBD from its list of banned substances; the Food and Drug Administration approved an epilepsy medication containing CBD oil for the first time, causing the U.S. Drug Enforcement Administration to shift its stance — albeit very slightly — on CBD.
Despite this, it's important to know that inflammation is not inherently bad; in fact, it's a brilliant aspect of our immune system. When balanced, inflammation heals wounds and fights off infections. The problem with inflammation arises when it increases and never calms down. Like a forest fire burning on in perpetuity, people get hurt. Same goes with the fiery squall of insidious, chronic inflammation. As a natural anti-inflammatory, CBD can help quell the flame and fight chronic inflammation.

Cannabidiol may play a therapeutic role in sleep regulation (Monti, 1977; Chagas et al., 2014b). In healthy volunteers with regular sleep cycle, 600 mg of CBD induced sedative effects (Zuardi et al., 1993), whereas in subjects with insomnia, acute use of CBD (160 mg/day) was associated with an increase in total sleep time and less frequent awakenings (Carlini and Cunha, 1981). Daily CBD doses of 40, 80, or 160 mg were shown to reduce dream recall and did not cause ‘hangover’ effects compared to placebo (Carlini and Cunha, 1981).


In a series of placebo-controlled studies involving 15 healthy volunteers, Fusar-Poli et al. investigated the effects of CBD and THC on task-related blood-oxygen-level dependent functional magnetic resonance imaging activation, specifically the go/no-go and fearful faces tasks [109, 110]. The go/no-go task measures response inhibition, and is associated with activation of medial prefrontal, dorsolateral prefrontal, and parietal areas [111]. Response activation is diminished in PTSD and other anxiety disorders, and increased activation predicts response to treatment [112]. CBD produced no changes in predicted areas (relative to placebo) but reduced activation in the left insula, superior temporal gyrus, and transverse temporal gyrus. The fearful faces task activates the amygdala, and other medial temporal areas involved in emotion processing, and heightened amygdala response activation has been reported in anxiety disorders, including GAD and PTSD [113, 114]. CBD attenuated blood-oxygen-level dependent activation in the left amygdala, and the anterior and posterior cingulate cortex in response to intensely fearful faces, and also reduced amplitude in skin conductance fluctuation, which was highly correlated with amygdala activation [109]. Dynamic causal modeling analysis in this data set further showed CBD reduced forward functional connectivity between the amygdala and anterior cingulate cortex [110].


This evidence supports the idea that CBD decreases autonomic stress responses (e.g. increased blood pressure, faster heart rate, etc.) associated with stress in animal models.  Additionally, the reduction in stress associated with CBD is induced predominantly via its binding to the 5-HT1A receptor sites.  Based on the results, we could speculate that CBD may be equally therapeutic in attenuating exaggerated autonomic stress responses in humans.

Constant and intense worrying about things (money, health, family, work, or other issues) when objectively there’s little or no reason for concern. People with Generalized Anxiety Disorder are anxious about getting through the day, they imagine things to be much worse than they are and expect everything to go bad. Even though they’re aware of the unnecessary overreaction to situations, people with GAD feel helpless and cannot control their anxiety. Generalized Anxiety Disorder affects 6.8 million adults, or 3.1% of the U.S. population. Women are twice as likely to be affected as men.
Anxiety disorders are far more serious and can prevent you from maintaining a normal life. Some have said that anxiety is not a disease or illness, but rather a physiological, psychological-emotional state that occurs when we behave apprehensively. It turns into a disorder when the worry and the anxiety it creates interfere with your lifestyle. Ongoing anxiety can lead to numerous medical illnesses and even mental issues, if not dealt with.
Depending on which hormone is stimulated, cannabis can boost or suppress appetite. For this reason, cannabis oil can help patients with eating disorders or be a natural way to treat obesity. This manipulation of the cannabinoid system is becoming popular, and more research is being done to determine its efficacy for patients with weight concerns. (6)
CBD oil is made by mixing the extracted CBD or cannabidiol from the cannabis or marijuana plant (Cannabis Sativa) with coconut or hemp seed oil. CBD oil possesses cannabidiol; while THC is psychoactive, CBD is not, thereby helping relieve pain, treating anxiety and depression, fighting cancer, reducing anxiety. It also improves the quality of sleep, boosts appetite, and optimizes digestion.

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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