The 5-HT1A receptor (5-HT1AR) is an established anxiolytic target. Buspirone and other 5-HT1AR agonists are approved for the treatment of GAD, with fair response rates [50]. In preclinical studies, 5-HT1AR agonists are anxiolytic in animal models of general anxiety [51], prevent the adverse effects of stress [52], and enhance fear extinction [53]. Both pre- and postsynaptic 5-HT1ARs are coupled to various members of the Gi/o protein family. They are expressed on serotonergic neurons in the raphe, where they exert autoinhibitory function, and various other brain areas involved in fear and anxiety [54, 55]. Mechanisms underlying the anxiolytic effects of 5-HT1AR activation are complex, varying between both brain region, and pre- versus postsynaptic locus, and are not fully established [56]. While in vitro studies suggest CBD acts as a direct 5-HT1AR agonist [57], in vivo studies are more consistent with CBD acting as an allosteric modulator, or facilitator of 5-HT1A signaling [58].
It is known that lack of sleep can interfere with certain aspects of cognitive functioning, such as attentional levels (Goel et al., 2009) and PVT, which has a high sensitivity to measure responses that require selective attention (Basner and Dinges, 2011). However, the results of the present study did not show any significant impairment in either the reaction time or number of errors measured by the PVT, suggesting that the attention levels of the volunteers were preserved in the morning after the sleep assessment, regardless of the administration of CBD or placebo. Not having administered the PVT test before CBD and placebo administration does not significantly affect the conclusions once the study does not intend to assess the effect of CBD on baseline vigilance (which would require comparison with baseline PVT results), but to rather evaluate if CBD may be safely administered to patients without affecting their vigilance state overall, such that the patients may safely conduct every-day tasks, like for example driving.

The CBD utilized in our tinctures is extracted from industrial hemp cultivated in the United States. To further ensure quality and purity, our industrial hemp goes through a supercritical CO2 extraction process to obtain the best possible CBD solution. This solution is then formulated by our board-certified pharmacists into finished products and sent out for third-party testing. Our CBD oil is made with high-quality CBD extracted from organic hemp that is abundant in naturally produced terpenes, oils, vitamins, omega fatty acids, and other components.
In the United States, cannabidiol is a Schedule I drug under the Controlled Substances Act.[60] This means that production, distribution, and possession of CBD is illegal under federal law. In addition, in 2016 the Drug Enforcement Administration added "marijuana extracts" to the list of Schedule I drugs, which it defined as "an extract containing one or more cannabinoids that has been derived from any plant of the genus Cannabis, other than the separated resin (whether crude or purified) obtained from the plant."[61] Previously, CBD had simply been considered "marijuana", which is a Schedule I drug.[60][62]
Please note that we are not qualified to give medical advice. ur CBD oil is made from high quality hemp at 5% and has a base of extra virgin olive oil. CBD oil has less than 0.2% THC in it, that's one of the reasons why it's legal in the first place. The effects will vary from person to person, but we are receiving very good feedback from customers who have bought our oil. We always recommend to start with a small dosage and increase if you do not feel any effect.

Hello everyone I’m kimberly a 25 year old mother & wife. I’ve been suffering with extreme anxiety and panic attacks since August of 2016 every single day now and it was so bad I couldn’t leave my bedroom I didn’t want to eat or anything I felt dead and I was always running to the hospital or doctors because I thought I was dying when I would have an attack. I even tried Xanax, Ativan, Betta blockers & some other medicine the doctor prescribed and omg it made it worse I felt brain foggy & weird so I stopped it after almost two months. I was a person who love to drive anywhere and travel and do things with my family and dirt bike ride and work etc but I became so afraid of Everything I lost my job and lost so much weight and man it was bad and last year I became pregnant and for six months my anxiety and panic attacks weren’t so bad they calmed down & I was able to cope with it and relax a little better. I use to smoke marijuana until one day I smoked something very strong & I was so paranoid it was scary so I stopped smoking (this was before I was pregnant) well after I had my baby this past December my anxiety & panic attacks are coming back strong again. I feel warm feeling in my head and pain lower part of the back of my head, dizziness, nausea, mind racing, heart palpitations & shaky & etc I’ve experienced a lot & I’ve been checked for everything & I am healthy I just need to exercise more I’ve even had a mri & ct scan & they saw nothing wrong.. I’m tired of this I cannot keep living like this. Everyday I’m scared to do anything. My brother purchase CBD Thclear 100mg pineapple flavor and I want to try it but I’m so scared (I’m scared of everything now smh) but I have been told by many that it will help me. As I’m typing this I’m having pain traveling to back of my head from my back smh. I want to get better everyone I need my life back and I miss interacting with my children especially and my spouse. Everything I feel I get scared. Has anyone tried it? I don’t want medication I wana try natural things or the CBD. Nobody around me understands what I am feeling so I need to speak to others who experience depression and anxiety panic attacks please. I want to get better oh and currently I have sinus infection I’m taking antibiotics for but I want to try the cbd but don’t know will it make me feel crazy or mess with the antibiotics? The CBD has no thc in it. And also the antibiotics seems make my anxiety worse any home remedies or can cbd help that also? I’ve mever had sinus problems or sinus ever until last year. I’m having pain right side of my back near my shoulder right now that’s travelkmg and to head could be medicine or Wendy’s I ate earlier so I’m going end this before I start to panic again
The following medications and other supplements may interact with CBD. Effects may include increasing or decreasing sleepiness and drowsiness, interfering with the effectiveness of the medications or supplements, and interfering with the condition that is being treated by the medication or supplement. These are lists of commonly used medications and supplements that have scientifically identified interactions with CBD. People who take these or any other medications and supplements should consult with a physician before beginning to use CBD.
@parus i just got my certification for medical marijuana. Upon buying what was recommended I was given CBD oil, I’ve not been on it a week yet today will be my fourth day of using it. It takes about 1/2 hour to work but it seems to help. They also gave me a cannabinol patch to use at night fir the severe itch in my head from the shingles. Also a vape two puffs as needed for the itch break through which I have not tried yet. I’m a bit anxious about using it.
Hi, Congrats on finishing chemo & radiation that’s awesome!! I wish you the best of luck!! I was actually wanting to know about dosage for cancer as well..My parents both have recently been diagnosed with cancer 4 months apart and are currently going thru chemo together. I have tried looking for the dosage info but can never find what i’m looking for..I want to try to help lesson the chemo side effects and hopefully kill some of the cancer cells. Can someone please help us?Thank You Christy
Further testing found what the world now knows: This compound is the plant’s principal active ingredient, its mind-altering essence—the stuff that makes you high. Mechoulam, along with a colleague, had discovered tetrahydrocannabinol (THC). He and his team also elucidated the chemical structure of cannabidiol (CBD), another key ingredient in marijuana, one that has many potential medical uses but no psychoactive effect on humans.
This figure, if accurate, is indeed a substantial number, especially when you take into account the different factors that may be behind this inability to get a decent sleep. If this number is reflective of a population that struggles with getting adequate amounts of sleep, it might suggest a strong need for a remedy that doesn’t mean over-prescribing pharmaceutical sedatives.
People claim that cannabis oil can be used to treat a wide range of conditions, though evidence to back up these claims is often lacking. For example, according to Medical News Today, people use cannabis oil for conditions ranging from pain to acne; some even claim the oil can cure diseases like Alzheimer's and cancer. (But again, there is no clinical evidence to support these claims.) 

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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