James Joliat, a 35-year-old video producer in Denver, has long experienced muscle and joint pain—mostly related to sports injuries. He says he started looking at natural remedies as an alternative to the prescription patches and pills his doctor recommended. After experimenting with homemade rubs infused with plant compounds—stuff like arnica and turmeric—he eventually stumbled onto topical cannabidiol (CBD) rubs.
According to the case report, it was charted by the girl’s oncologist that the patient “suffers from terminal malignant disease. She has been treated to the limits of available therapy … no further active intervention will be undertaken.” She was then placed in a palliative home care and told to prepare for her disease to overwhelm her body. She was expected to suffer a stroke within the next two months.
Kane fingers one of his innocuous-looking plants, expressing mild bemusement at the U.S. ban on commercial hemp cultivation. “Hemp produces fibers of unparalleled quality,” he notes. “It’s a tremendously high biomass crop that replenishes the soil and doesn’t require much in terms of inputs. We import tons and tons of hemp each year from China and even Canada, yet as a matter of federal policy, we can’t legally grow it. There are places where farmers in the U.S. can literally look across the Canadian border and see fields that are yielding huge profits.”
Two cannabis-based pharmaceutical drugs, manufactured in the UK, are licensed for prescription but only for very specific uses. Sativex has been available in the UK since 2010 and uses THC and CBD to treat spasticity in multiple sclerosis. And a new CBD-only drug, Epidiolex, was approved in June in the US to treat rare childhood epilepsies, with a similar decision expected imminently for Europe and the UK.
Hi I've had rsd over 25 years now and in stage 3 I take cbd I'mor nong 6 weeks now and it's helped tons w my depression,sleep,constipation as well as energy. I take 2 drops under tounge every morning and Rick spson oil 3 xs day.It's bern beyond life changing for me look into the rs oil w the cbd. It works.. I still take 1 opiad a day have taken 2 a day only 3 times in almost 2 months when I was in bad flare ..
The definitions of hemp and marijuana can get pretty confusing, but for basic purposes, marijuana contains high levels of THC, and hemp contains low levels of THC. The ratios of CBD to THC in hemp oil can vary, depending on the product and the specific plant the oil was extracted from. CBD oil, a concentrated version of the cannabidiol compound, is typically derived from hemp but can be extracted from marijuana as well. CBD oil products on the market have varying levels of CBD and THC. Many have little to no THC, while some contain small amounts.
My MD has prescribed at least 20 different BP drugs for me, but I do not feel that any really worked; and some were so dangerous that I refused to used them more than one or 2 nights, and then would disgard them, especially after reading about the possible side effects. Never tried CBD oil, but my guru nutritionist has given me a bottle of 1200mg organic hemp oil from Veggimins and I have been hesitant to really try it.
(FYI, if you're concerned about whether or not Charlotte's Web is legal, their PR kindly sent me this statement: "Regarding legality, CW Hemp is compliant with U.S. law regarding the manufacture and sale of dietary or food supplements. Our products meet the EU standard of less than 0.2% THC to be regarded as hemp and we market our products as a food supplement and adhere to those labeling laws." Phew.)
Hemp oil has never been as popular as other marijuana products. With little to no THC, CBD-rich strains of cannabis don’t deliver the pleasant buzz recreational users seek out in marijuana. In the 1970s, however, scientists found that cannabidiol was effective in reducing seizures. The brain’s endocannabinoid system contains receptors that respond to CBD, producing anticonvulsant effects. Being plant-derived and native to the brain’s own chemistry, CBD is therefore one of the most natural options for seizure treatment available today. Still, not many people took interest in CBD until 2013, when a CNN documentary special, Weed, hosted by the network’s chief medical correspondent, Dr. Sanjay Gupta, highlighted CBD’s effectiveness in combating seizures. Since then, demand for hemp oil products has exploded.
“By smoking weed, you suppress the REM sleep, and with that you also suppress a lot of important functions of that REM sleep. One of those functions is reliving the things you have experienced and coming to terms with them, as it were. Processing all kinds of psychological influences is something you do in REM sleep. You also anticipate the things that will happen the next day or the days after that. While you're sleeping, you already consider those and make decisions in advance."
To this point, CBD oil has existed in a kind of liminal space— at once an illegal drug, a legal medication, and some kind of “dietary” supplement. It’s possible this could change in the coming years, however. GW Pharmaceuticals, a U.K.-based firm, has developed a “pure CBD” medication called Epidiolex that has shown promising test results. It is currently on a fast-track to receive FDA clearance. For some patients, Epidiolex could be a miracle cure. This summer, in Wired magazine, writer Fred Vogelstein chronicled his family’s own struggles to find an effective treatment for his son’s epilepsy—including experiments with hemp oil— and the immense hurdles they overcame to gain access to Epidiolex prior to its FDA approval. The drug could be for sale on pharmacy shelves in the near future, though exactly how near is hard to say.

Welcome to Mayo Connect. I am a Volunteer Mentor and not a medical professional. As such I can offer the benefit of my personal experience, as can others on this site, but not medical diagnoses nor medical opinions. We strive to help each other with the understanding that we are all different and what works for me may not work for you. I have gotten so much good from participating in Mayo Connect that I love it.

When Brandon Krenzler’s daughter Mykayla was diagnosed with a form of childhood leukemia in 2012 at the age of seven, he began researching medical marijuana products that might ease her symptoms and blogging about the results. The next year, he received some samples of Real Scientific Hemp Oil, which he administered to Mykayla. But the oil made her sick.
In order to manage sleep disorders, we recommend ingesting full spectrum CBD oil daily in the form of Tinctures or Gel Capsules. The ingredients in the two products are the same, the only difference between the two is the form factor and dosage – pills vs. sublingual tinctures. The time at which you should ingest the CBD oil will vary based on your specific sleeping disorder. Meaning those with insomnia should ingest a few hours before bed and those with excessive daytime fatigue should consume when waking in the morning. 
The case study notes that advanced chemotherapeutic agents had failed to control the blast counts (cells in the blood and bone marrow) in the patient and had devastating side effects that ultimately resulted in death. The cannabinoid therapy, on the other hand, had no toxic side effects and only psychosomatic properties, with an increase in the patient’s vitality.

In my second experience with CBD, I decided that I needed to double up the dose to determine whether I could enhance the anxiolytic effect.  Keep in mind that this was weeks after my first administration with zero CBD usage in between.  This time I decided to take 2 capsules of the BioCBD+ in the evening at around 6:00 PM prior to grocery shopping.
Cannabidiol offers a novel pharmacodynamic profile as an anxiolytic agent.  It is believed that administration of CBD (cannabidiol) modulates neurotransmission in a multitude of ways.  Literature shows that cannabidiol alters 5-HT1A, GPR55, CB1/CB2, and mu/delta opioid receptor sites – while simultaneously enhances hippocampal neurogenesis.  The combination of these neurophysiological effects likely contribute to its efficacy as a novel anxiolytic.
Endocannabinoids are familiar to runners because of their theorized role in running-induced mood boosts. That euphoric phenomenon is thought to be from activation of the same receptors in the brain that the tetrahydrocannabinol (THC) in marijuana acts upon. CBD “works through distinct—albeit not definitively identified—signaling systems than THC,” DiPatrizio says. CBD is non-psychoactive, which means it doesn’t produce a high.
Ganja is simply around us more, its unmistakable but increasingly unremarkable smell hanging in the air. Yes, smoking it may lead to temporary laughing sickness, intense shoe-gazing, amnesia about what happened two seconds ago, and a ravenous yearning for Cheez Doodles. Though there’s never been a death reported from an overdose, marijuana—especially today’s stout iterations—is also a powerful and in some circumstances harmful drug.
Another major reason people reported not being able to get to sleep, or maintain substantial sleep, was due to chronic pain. Many who suffer from insomnia say that they cannot find enough relief from pain to manage to get to sleep or at least to remain asleep through the night. A rodent study submitted to the European Journal of Pain noted a significant drop in inflammation and signs of pain in rats with arthritis after they received topical treatment of CBD for sleep.

“Strong data is lacking with CBD. There have been only small research trials some showing benefit, others showing no benefit with CBD,” said Pritham Raj, an internist-psychiatrist in Portland, Oregon. “So, in short, the jury is still out. This doesn’t mean CBD doesn’t work for anxiety, it just means that we don’t have enough information to make a strong argument for CBD in the treatment of anxiety.”


For some reason, Monday morning doesn't seem full of the usual oh my goodness, there could be a disaster around every corner situations I normally conjure up in my mind. Maybe it's because it's sunny outside (always a bonus); maybe it's because my brain is fuzzy with phlegm; maybe it's because my nose piercing, fed up with endless nose-blowing, is pulsating in pain. Maybe it's the oil. Either way, I spend the afternoon praising the oil, wishing I could bathe in it. The phlegm may be causing me to lose it a little.
Industrial hemp, on the other hand, comes from the engineered Cannabis Sativa strain, which contains only trace concentrations of THC. Although hemp falls under the cannabis category, it’s different from the cannabis plant that’s grown for medicinal or recreational purposes. CBD from industrial hemp doesn’t produce the euphoric buzz that’s commonly associated with intake of marijuana-based CBD oil.

“THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”


58. Rock EM, Bolognini D, Limebeer CL, et al. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol. 2012;165:2620–2634. doi: 10.1111/j.1476-5381.2011.01621.x. [PMC free article] [PubMed] [Cross Ref]


Hippocampal neurogenesis: One hypothesized mechanism by which pharmaceutical anxiolytics may decrease anxiety is via hippocampal neurogenesis – or growth of new neurons within the hippocampus.  It appears as though cannabidiol administration induces hippocampal neurogenesis in animal models, and for this reason, similar outcomes may occur in humans.  A rat study involving the chronic administration of 5-HT1A partial agonist (tandospirone) increases the biomarker of doublecortin – indicating emergence of new neurons in the hippocampus.

During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.
For the study, researchers recruited 8 volunteers and administered the following: THC (0.5 mg/kg), CBD (1 mg/kg), CBD/THC mix OR Valium (10 mg) or placebo (serving as controls).  The volunteers each received the combinations in an order different from the others.  Researchers were able to verify that CBD inhibited anxiety as induced by THC, but physiological data revealed it was not a result of direct THC inhibition.
It’s important to remember that Tetrahydrocannabinol oil has psychoactive properties, so it’s still illegal in states where medical and/or recreational use of marijuana is prohibited. Aside from the illegal nature of THC, many health professionals and medical authorities question it’s efficacy as a treatment option since comes with such profound psychoactive effects. In fact, many doctors and researchers see the oil as more dangerous than it is beneficial.
Dr. Ethan Russo, medical director at Phytecs, a biotechnology company spearheading research into plant- based medicines and the endocannabinoid system, took issue with Titus’s claim, however. “Bioaccumulators can recruit heavy metals from the soil,” Russo said, “but breaking them down would be alchemy.” Government regulation of the pharmaceutical industry is designed to protect consumers from unfounded scientific claims.

In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act, which imposed a levy of $1 per ounce for medicinal use of cannabis and $100 per ounce for recreational use. This was opposed by physicians who were not required to pay a special tax for prescribing cannabis, use special order forms to obtain it and keep records detailing its professional use. The American Medical Association believed that evidence of cannabis’ harmful effects was limited and the act would prevent further research into its medicinal worth.
I have been on prescription medication for insomnia. It is called Lunesta. I would like some advise on how to get off this medication by using CBD oil. I am cutting the medication is half each night and using CBD gummies with it. I am not getting very good results.Any advice on this would be appreciated. I tried 40 milligrams of the CBD gummies and half of a 3 milligram Lunesta..I couldnt get to sleep until about 3 in the morning. Help please
“I just felt good,” he adds. “But I wasn’t high at all.” Joliat’s anecdotal experience with CBD is a common one. Some informal polling suggests a lot of people today are at least vaguely familiar with cannabidiol, and have either used it themselves or know someone who has. But even some people who use it don’t seem to know exactly what it is or whether there’s any hard science out there to back up its benefits.
That headache study cites research linking CBD to lower rates of anxiety. (Since anxiety often produces headaches, the authors say, CBD could be a plausible headache remedy if those anti-anxiety benefits are legit.) Grant says he’s looked at the literature on CBD and anxiety, and some of it is enticing. He mentions a Brazilian study, for instance, that found people with a fear of public speaking felt less anxiety and less discomfort about their phobia after taking CBD, compared to those who took a placebo.

A research conducted by Ethan B Russo, GW Pharmaceuticals, WA, USA, suggests that CBD oil interacts with the protein cells in the body and sends chemical signals to your brain and immune system through a number of stimuli. This helps the cells positively respond to chronic pain. This oil is regularly suggested for people with inflammation and back pain because of its painkilling quality.


Grant says this may lead to a “dampening” or mellowing of some neurochemical processes, including those linked to pain. “CBD may also react with other receptors, like those for serotonin, and it may have actions that reduce the inflammatory molecules produced whenever there is tissue damage or bacteria coming in,” he says. “But we really don’t know the mechanisms.”
Two cannabis-based pharmaceutical drugs, manufactured in the UK, are licensed for prescription but only for very specific uses. Sativex has been available in the UK since 2010 and uses THC and CBD to treat spasticity in multiple sclerosis. And a new CBD-only drug, Epidiolex, was approved in June in the US to treat rare childhood epilepsies, with a similar decision expected imminently for Europe and the UK.

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