We're on the edge of a CBD explosion. The U.S. market for CBD products is estimated to be worth $2.1 billion by 2020, up 700 percent from 2016; the World Anti-Doping Agency removed CBD from its list of banned substances; the Food and Drug Administration approved an epilepsy medication containing CBD oil for the first time, causing the U.S. Drug Enforcement Administration to shift its stance — albeit very slightly — on CBD.
“These studies mainly point to CBD’s ability to interact with ... serotonin receptors and GABA receptors in the brain,” she explained. “Serotonin plays an important role in mood and anxiety, and GABA is known as the main ‘inhibitory’ neurotransmitter, meaning it calms excess activity in the brain and promotes relaxation. GABA receptors are the target of benzodiazepines, which are a class of anti-anxiety drugs.”
My mother has dementia/Alzheimers along with a broken knee that they will not repair do to her mental status. She is currently in a nursing home. I firmly believe her mental situation began with the over use of hydrocodone for over 30 years and was acerbated by the trauma of breaking and disconnecting her knee cap. Since weaning her off of her meds (still in progress) we have regained much of her consciousness. I want to try CBD to help in her recovery or to help slow down the disease. I cannot find a dosage recommendation plus the nursing home/doctor does not recommend it. I would need to give it to her when I am there visiting (about 3 - 4 times per week). Is there a recommended dosage for dementia/Alzheimers?
For kids with severe forms of epilepsy, changes in medication levels can be extremely dangerous. “If their levels go low, they’re at increased risk of seizures, which could lead to an emergency room visit or an ICU stay,” Knupp said. “On the other hand, if their levels go high, their side effects can increase dramatically.” Side effects from epilepsy medications can range anywhere from drowsiness to vomiting to heart arrhythmia, Knupp noted. “For some people that could mean a minor inconvenience, but for some patients it could be life-threatening.”
Tolerance: It is possible that someone who uses CBD oil often could become tolerant to its effects. This is because no drug is capable of bypassing the endogenous homeostatic mechanisms of the human body.  If something were capable of doing so, people could remain on an anxiolytic and/or antidepressant for an indefinite period of time without any decreased efficacy.  Unfortunately, it is likely that if used too frequently, tolerance will ensue and an individual will require greater doses to maintain a therapeutically anxiolytic effect.
Why stress happens and how to manage it Stress is essential for survival; the chemicals it triggers help the body prepare to face danger and cope with difficulty. Long-term stress is linked to various health conditions and can cause physical and psychological symptoms. How is it diagnosed, what types of stress are there, and how is it treated or managed? Read now
On the other hand, a 2017 comprehensive review of CBD studies in psychiatric disorders found inconclusive results. According to the authors, there isn’t enough evidence to claim CBD as a treatment for depression. However, the authors do note positive results for anxiety disorders. Based on their review, more human tests are needed to better understand how it works, what ideal dosages should be, and if there are potential side effects or hazards.
“It can affect everything from emotion to pain to appetite to energy metabolism to brain function to even the immune system and inflammation,” says Hector Lopez, M.D., a consultant to PlusCBD Oil, one of the top-selling brands. “When you have a system that cross talks with all those pathways, then there are very few things the endocannabinoid system does not influence.”
General health improvement: Intermittent usage of CBD oil on an “as-needed” basis is understood to provide numerous general health benefits. Research suggests that CBD oil may offer anticancer, analgesic, and antiemetic properties.  There’s evidence noting that it may boost immune function, slow the growth of bacteria, reduce muscle spasms, and modulate blood sugar levels.  Literature indicates that cannabidiol may be conducive to general health.
To access CBD oil, a solvent extraction process is required, which returns roughly 3-5 grams of oil per ounce of flower product used. Using grain or isopropyl alcohol as a solvent, you can strain the result of the mixture, leaving CBD oil behind. It is a lengthy process, and in countries where cannabis is legal, there are many places to access high-quality CBD oil.

Therefore, it is important to realize that potency of CBD oil that you attain will be subject to variation based on the sourcing and its formatting.  Additionally, there’s no way to recommend an “optimal” universal dose for all types of anxiety as different dosages may be necessary based on the specific subtype of anxiety disorder.  For example, a person with PTSD may require a slightly different dose than someone with social phobia.
A study published in 2008 indicated that CBD injections into the dorsolateral periaqueductal gray area of rats reduced anxiety via 5-HT1A receptor interaction.  Researchers noted that the 5-HT1A receptors were more involved than cannabinoid receptors (e.g. CB1) in reducing anxiety.  The study concluded that cannabidiol interacts directly with 5-HT1A receptors to yield an anxiolytic response.
Has anyone done the math? How much could 40mg of CBD cost/night? How much would 160mg cost? The problem is the recommended dose and doses available on the market do not jive. Why the discrepancy between dose recommended by researchers and dose available in the products? Will higher CBD oils be available in the future? For me, right now it would cost $90 to get to sleep on CBD. Totally unrealistic.
For instance, some people report a sense of calm and peace; others report increased anxiety levels and unpleasant sensations. The intensity of these symptoms will largely depend on an individual’s body composition. In addition, marijuana strains feature different levels of oil concentration that also determines the intensity of the outcomes that a user feels after consumption. Some strains are recommended to produce less profound symptoms and reactions.

In an initial experiment, the male Wistar rats received injections of CBD and were exposed to 60 minutes of restraint stress – with cardiovascular responses recorded.  In a second experiment designed to determine effects of CBD on the 5-HT1A receptor, researchers administered a 5-HT1A antagonist prior to the CBD.  Precisely 24 hours after CBD administration, the Wistar rats were tested in an elevated plus-maze to gauge anxiety.


Adjunctive option: Many speculate that CBD could bolster anxiolytic effects of various first-line pharmaceutical agents. Since likelihood of CBD interacting with other agents is minimal, it may serve as a novel adjunctive option for those with severe anxiety.  In other words, someone who fails to derive sufficient benefit from a first-line option may find that addition of CBD (on an “as needed” basis) fully attenuates anxious symptoms.

On the federal level, several bills currently before Congress seek to change the way the government treats CBD. One such bill, the Compassionate Access Act, would exclude CBD from the classification of “marijuana” and remove both from the DEA’s list of Schedule I controlled substances. Rescheduling CBD in such a way would make research and cultivation of CBD much easier.
THC, an intoxicating and illegal substance, is responsible for causing marijuana users to get “high.” Unlike THC, CBD is non-psychoactive because it does not act on the same pathways as THC. Thus, it is impossible to get “high” by smoking or ingesting CBD or CBD oil extracted from industrial hemp plants, as they only have minuscule traces of THC (<0.3%).
As Kane leads me around his lab, I see the excitement on his face and on the faces of his young staff. The place feels almost like a start-up company. “So much of science is incremental,” he says, “but with this cannabis work, the science will not be incremental. It will be transformative. Transformative not just in our understanding of the plant but also of ourselves—our brains, our neurology, our psychology. Transformative in terms of the biochemistry of its compounds. Transformative in terms of its impact across several different industries, including medicine, agriculture, and biofuels. It may even transform part of our diet—hemp seed is known to be a ready source of a very healthy, protein-rich oil.”
It is unclear as to what the optimal dosage of CBD is for anxiety disorders.  Most literature suggests that a single 600 mg dose of CBD is sufficient to alleviate anxiety.  However, the source from which you attain your CBD may make a major difference.  Various companies are selling CBD formatted with nanotechnology and/or co-factors (to maximize bioavailability) and a significantly lesser dose may be required than agents without specialized formatting.
Do you have a medical marijuana card? I would suggest finding some indica edibles (they will have THC and maybe some CBD). Start with 7 to 10 mg’s of THC and slowly increase dosage on your next try if nothing happens. Whenever I have an indica strand edible, I sleep like a rock. Maybe even a separate dose of CBD could be beneficial to the THC edible. Everyone reacts different, so it’s best to start slow and gradually increase your dose until you find what works for you.

The CBD oil needs to be taken twice a day everyday. The dosage depends on symptoms and it takes 30 days to awken your natural cannabis system after you begin taking the oil. I personally use Hemp works CBD oil in the 750 strength and only need 5 drops sublingual 2 times daily and results are many. Problem with oil and alz.patients is getting them to hold oil under tongue for 60 seconds. We have just began to get my dad on it. He too is in a nursing home in the state of florida and they cannot deny him any medication my mom has requested that he receive. If she is not their they are supposed to administer and she will call them to make sure he gets it. He is not 30 days into dosing yet so I don't have any results to speak of. I do know that since he has started he has had no more bladder infection and has not fallen in 3 weeks. That's a record for him so we will continue to monitor. Best of luck to you and a lot is going to depend on the state your mom is in and what the state laws are concerning her rights or the rights of whom has her medical power of attorney


My husband was diagnosed with ALS (amyotrophic lateral sclerosis) when he was 61 years old 4 years ago. The Rilutek (riluzole) did very little to help him. The medical team did even less. His decline was rapid and devastating. His arms weakened first, then his hands and legs. Last year, a family friend told us about Rich Herbs Foundation (RHF) and their successful ALS TREATMENT, we visited their website www. richherbsfoundation. com and ordered their ALS/MND Formula, i am happy to report the treatment effectively treated and reversed his Amyotrophic Lateral Sclerosis (ALS), most of the symptoms stopped, he is able to walk and able to ride his treadmill again, he is pretty active now.

Rule #2 – Be consistent with your dosing. Don’t start small and then jump to higher doses. It’s important that your body gets accustomed to the CBD, so gradually increase the amount over time. Also, don’t get discouraged if you do not notice effects immediately – some people have said it took them up to two weeks of daily use before they started noticing positive results.
Do you have a medical marijuana card? I would suggest finding some indica edibles (they will have THC and maybe some CBD). Start with 7 to 10 mg’s of THC and slowly increase dosage on your next try if nothing happens. Whenever I have an indica strand edible, I sleep like a rock. Maybe even a separate dose of CBD could be beneficial to the THC edible. Everyone reacts different, so it’s best to start slow and gradually increase your dose until you find what works for you.
Grant says this may lead to a “dampening” or mellowing of some neurochemical processes, including those linked to pain. “CBD may also react with other receptors, like those for serotonin, and it may have actions that reduce the inflammatory molecules produced whenever there is tissue damage or bacteria coming in,” he says. “But we really don’t know the mechanisms.”

Lidicker noted that one study on humans, published in the journal Neuropsychopharmacology, showed that CBD was able to help with public speaking-induced anxiety. She also pointed to a clinical trial that started in August at a hospital in Massachusetts, in which researchers are administering 10 mg of CBD three times a day for a month to test its effects on patients with anxiety.
In order to manage sleep disorders, we recommend ingesting full spectrum CBD oil daily in the form of Tinctures or Gel Capsules. The ingredients in the two products are the same, the only difference between the two is the form factor and dosage – pills vs. sublingual tinctures. The time at which you should ingest the CBD oil will vary based on your specific sleeping disorder. Meaning those with insomnia should ingest a few hours before bed and those with excessive daytime fatigue should consume when waking in the morning. 
This is a topic I am asked about all the time, and have been for years: how does cannabis help sleep and health? I’ve heard that the number-two reason why people smoke or use cannabis is for sleep. Considering the recent passing of the recreational use of cannabis in California and other several states I think it is high time (pun intended!) to look at CBD, one of the most active ingredients in medical cannabis.
Adenosine 2A receptor: Administration of CBD is thought to act upon the adenosine 2A receptor site, possibly contributing to its anxiolytic and anti-inflammatory effects.  Adenosine receptors are known to influence cardiovascular processes (cardiac rhythm, circulation), immune function, sleep, pain regulation, and blood flow.  The adenosine 2A receptor interacts with G proteins to alter cAMP (cyclic adenosine monophosphate).  Dysfunction of the adenosine 2A receptor may disrupt neurotransmission of glutamate and dopamine, and simultaneously cause inflammation, neurodegeneration, and possibly anxiety.
The DEA isn’t the only government agency scrutinizing CBD vendors. To fend off the FDA, hemp oil companies contend their wares are not drugs but “dietary supplements.” Despite the suggestive “meds” in the company’s name, HempMedsPx is careful to note on its web site, “Although some of our founders are medical professionals, we cannot make medical claims about the benefits of our products.” Others are not quite so nuanced in their marketing. The internet is flooded with CBD products claiming to treat everything from seizures to arthritis to skin conditions and other maladies.
Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.[71]
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Long-term outcomes: There are zero long-term studies investigating the safety, efficacy, and long-term effects of CBD as a treatment for anxiety. Data from animal model studies suggests that chronic CBD usage could yield deleterious epigenetic and/or neuropsychiatric effects. However, it is unclear as to whether administration of CBD at a normative (non-chronic) frequency would maintain therapeutic efficacy over a long-term.
PTSD sufferers usually re-experience the trauma in their dreams, which drastically disturbs their REM sleep and overall sleep patterns, leading to insomnia. In a case report on a 10-year old girl suffering from PTSD, a trial of cannabidiol oil resulted in a maintained decrease in anxiety and a steady improvement in the quality and quantity of the patient’s sleep.
In the past few years, just such a cure has seemingly presented itself. Amid the less common remedies that can be found on the internet—special diets, meditation, biofeedback, surgical implants—a new product has recently gained prominence: CBD oil (sometimes known simply as “hemp oil”), so named for its chief chemical compound, cannabidiol, which occurs naturally in cannabis plants. In online forums and news articles, CBD has been hailed as a new frontier in epilepsy treatment, with parents testifying that it managed to stop their children’s seizures when nothing else could.
“This is a really powerful compound,” says Mikhail Kogan, the medical director of the George Washington University Center for Integrative Medicine. “I’ve seen it work for a lot of my patients.” He prescribes high-CBD strains of cannabis regularly for such illnesses as epilepsy, post-traumatic stress disorder, anxiety, autoimmune disorders, autism and insomnia.
Whether the claim of 10-fold bioavailability of nano-engineered CBD can be scientifically verified isn’t known, however, preliminary testing from the company suggests that 10 mg of their product is equivalent to 100 mg of others.  Assuming the nano-engineering is effectively increasing bioavailability by 10-fold, each BioCBD+ capsule I’ve taken (with 10 mg CBD) is delivering the equivalent of 100 mg standard CBD.
That's why it's being increasingly used as a sleep aid, she says. "The major reason why most people don't sleep is because they're stressed out, they're anxious, they can't shut their brain off," she explains. "What CBD does is calm down your body's stress response and bring those cortisol and adrenaline levels back to baseline." Science is scant, but what studies we do have back that up: CBD may increase the amount of time you sleep, according to an animal study published in the Journal of Psychopharmacology, and improve insomnia, research in the journal Current Psychiatry Reports found.
For people who suffer from insomnia, constant anxiety during the night or simply struggle to get a sound, restful night of undisturbed sleep, cannabis sativa essential oil may work like a charm. However, according to a research report published by Dr. Ethan Russo, Director of Research for the International Cannabis and Cannabinoids Institute, terpenoids produce an “entourage effect”.
I recommend CBD International to everyone I know who is fighting cancer including the Hospice team taking care of my daughter. All the different nurses always ask, they have many patients asking. If I can save anyone the three months it took me to find you, that time saved could save a life. When you find yourself in a situation like a cancer diagnosis, you are searching for something to help, you really don't know what you are getting. My visits to the medical marijuana shops in Southern California left me frustrated, they are not knowledgeable and kept steering me to edibles and hash oil and trying to find the correct treatment was for me, about the only thing I could do for my daughter that might help her and the only thing she was willing to try. From the very first contact on your website, to the questionnaire to all correspondence, so timely and the integrity and kindness you and your company have shown me, I can't praise you enough. You guys are the real deal.
REM stands for random eye movement. It is one of the phases of your sleeping process where eye movements become rapid, muscle tone reduces, and you are able to dream. The REM sleep seems to play an important role in keeping up one’s physical health, for it is during this period that the blood flow diverts towards the muscles, which gives time and space to your brain to take a break. Having troubles attaining REM phase of the sleep can certainly produce negative impact on your health, since if this is the case, your brain remains devoid of rest.

At age 5, Figi’s parents, Matt and Paige Figi, had exhausted all traditional options in their quest to control the hundreds of grand mal seizures their young daughter was experiencing every day. They ultimately turned to the Stanleys, a group of brothers who grow pot in Colorado, who then developed a groundbreaking hemp-based CBD oil they dubbed “Charlotte’s Web.”

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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