Hi Dr. Kevin. Thanks for your question. I have seen people react differently to CBD. For some, yes it can help them relax and sleep. For others, it can make them feel more energetic. And yes, unfortunately for some it may increase their anxiety. For those people, CBD would not be a good fit. You made a good observation about the possibility this has to do with the terpenes involved. There are some theories about that but I have no definitive knowledge on that being the cause.
“Strong data is lacking with CBD. There have been only small research trials some showing benefit, others showing no benefit with CBD,” said Pritham Raj, an internist-psychiatrist in Portland, Oregon. “So, in short, the jury is still out. This doesn’t mean CBD doesn’t work for anxiety, it just means that we don’t have enough information to make a strong argument for CBD in the treatment of anxiety.”
Hi, I had ovarian cancer stage 2 and went to do chemotherapy for 16 times in 2014. It came back last year 2016 but I did not do chemotherapy or radiation therapy as suggested by the doctor. I am taking hormone therapy at the moment. I would like to use cannabis oil but which one and how much CBD and how much THC should I take for ovarian cancer? Can anyone give some idea?. Thank you very much.
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The arrival of Epidiolex is unlikely to erase the unregulated CBD market, however. For one, Epidiolex has been studied only in connection with a small number of epileptic conditions. If and when Epidiolex makes its way to drug stores, it will be approved only for the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, two rare forms of catastrophic epilepsy. People like me, with comparatively mild Janz Syndrome, and people like Harper, with extremely rare conditions like CDKL5, may still be out of luck.

FAAH inhibitor: The anxiolytic efficacy of CBD may be a result of its ability to act as an enzymatic inhibitor of FAAH (fatty acid amide hydroxylase).  FAAH is an enzyme responsible for metabolizing endocannabinoids such as anandamide, but when inhibited, these endocannabinoid concentrations are increased.  Increased concentrations of endocannabinoids such as anandamide and 2-AG, both of which bind to peripheral CB1/CB2 receptor sites.
Even without changes at the federal level, there are steps that states could take on their own to make the CBD market safer. States with broad marijuana legality or CBD-only measures could mandate the calibration and regulation of testing labs, and use them to conduct safety testing. They could fund research into the benefits, dosing, and drug interactions of CBD through their public university systems. Medical boards could redouble efforts to educate physicians in what research exists regarding medical marijuana in all its incarnations, so that doctors are prepared to prescribe and manage these medications as they become available.

Taking CBD oil is like drinking milk and calling it calcium, Hernandez said: There’s some in there, but at very low concentrations dispersed among a host of other ingredients. And what those other ingredients are is anyone’s guess. “The thing to know is that CBD hasn’t gone through the safety controls, the efficacy controls that we usually use, the clinical trials,” Hernandez said. “The jury is still out regarding how safe this drug is.”


At first, I was wary. Although I live in Los Angeles, where it seems like there’s a medical marijuana depot on every corner, I’m not one for doing drugs (legal or otherwise). I mean, I don’t even take Advil when I get a headache!  But despite the fact that CBD oil is made from hemp, it doesn’t contain THC. THC is the compound responsible for the “high” that comes with ingesting marijuana. In fact, scientific reviews have proven that CBD “does not interfere with several psychomotor and psychological functions,” and is safe to ingest without any side effects. Let me repeat: YOU WILL NOT GET HIGH FROM CBD!

People who smoke cannabis often smoke it to get high and for its calming qualities, using cannabis specifically cultivated for very high amounts of THC content. Strains such as skunk are bred to contain as much of the psychoactive compound as possible, with THC levels increasing dramatically over the last few decades due to the popularity of THC’s effects for recreational users.
Although not as abundant as THC cannabinoid content, cannabidiol accounts for approximately 40% of all cannabinoids within cannabis extract.  Unlike THC, cannabidiol is non-psychoactive and isn’t typically ingested with the intent to attain any sort of psychological euphoria.  That said, the medicinal properties associated with cannabidiol (often administered in the format of “CBD oil”) are thought to far exceed those of THC.
Research works have been pretty favorable in describing the role of CBD in improvisation of REM sleep phase. For example, in a study, it has been found that CBD is effective in regulating REM sleep alteration that is induced by anxiety in rats. It is important to mention here that anxiety is an important risk factor of insomnia. Moreover, CBD is also employed for fighting off with anxiety.
Adenosine 2A receptor: Administration of CBD is thought to act upon the adenosine 2A receptor site, possibly contributing to its anxiolytic and anti-inflammatory effects.  Adenosine receptors are known to influence cardiovascular processes (cardiac rhythm, circulation), immune function, sleep, pain regulation, and blood flow.  The adenosine 2A receptor interacts with G proteins to alter cAMP (cyclic adenosine monophosphate).  Dysfunction of the adenosine 2A receptor may disrupt neurotransmission of glutamate and dopamine, and simultaneously cause inflammation, neurodegeneration, and possibly anxiety.
Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects. CBD’s anxiolytic actions appear to depend upon CB1Rs and 5-HT1ARs in several brain regions; however, investigation of additional receptor actions may reveal further mechanisms. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. Current preclinical and human findings mostly involve acute CBD dosing in healthy subjects, so further studies are required to establish whether chronic dosing of CBD has similar effects in relevant clinical populations. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders.
If I had to rate the efficacy of the second dosing option for anxiety on a scale of 1 to 10, I’d rate it about a 6.  Meaning, it was noticeably more effective than the first low-dose at even just 20 mg.  Perhaps in the future I’ll press my luck with an even greater dose of around 60 mg, which is equivalent to 600 mg CBD and the dosage that has been documented as effective for anxiety in clinical research.
We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.
Relevant studies in animal models are summarized in chronological order in Table ​Table1.1. CBD has been studied in a wide range of animal models of general anxiety, including the elevated plus maze (EPM), the Vogel-conflict test (VCT), and the elevated T maze (ETM). See Table ​Table11 for the anxiolytic effect specific to each paradigm. Initial studies of CBD in these models showed conflicting results: high (100 mg/kg) doses were ineffective, while low (10 mg/kg) doses were anxiolytic [59, 60]. When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose–response curve, with anxiolytic effects observed at moderate but not higher doses [61, 90]. All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [62, 65], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Campos et al. [66] showed that in rat, CBD treatment for 21 days attenuated inhibitory avoidance acquisition [83]. Long et al. [69] showed that, in mouse, CBD produced moderate anxiolytic effects in some paradigms, with no effects in others.

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Verified CBD is a great example that you shouldn’t judge the book by its cover. Although the information about the company is scant, and the team seems to be completely okay with that, once you engage into an e-mail conversation with them, you will get answers to absolutely any question that bothers you. Besides, when a company has been successfully selling their CBD goods to 50 countries around the world, there must be something in the water.
The equivalency factor is not designed to compare the effects of cannabis oil to dried cannabis, or provide dosage information. For many patients, consuming cannabis orally will produce much stronger effects than inhaling it. For example, when considering a product that has an equivalency factor of 12ml of oil to 1 gram of dried cannabis, and a patient who usually consumes 1 gram of dried product a day, this patient will likely use less than 12 ml of oil per day. Even for patients who have previous experience of using cannabis oil, it is recommend that you start with a low dose and go slow.
Bacon had said that I might need to try two full droppers worth of the oil to really feel its benefits. I knew that I had an incredibly busy and stressful day ahead of me—I needed to fit in a five mile run before work, had lots to do at the office, was scheduled for a busy event in the middle of the day, and had a 2-hour meditation class later that night which would require a lot of mental clarity. Tentatively, I squirted two droppers of CBD oil into my bulletproof coffee and sipped away.
Hi Eric, sorry to hear you are suffering. In regards to the oils, i am no doctor and tried a few before i found what works best for me. I think it depends on your condition and genetics. For example, I use green roads and it is extremely effective, but it doesn’t work for my wife. I think you have to find the one that works for you. Maybe someone else can who has more experience can also help.

Hey Cynthia. Thanks for your inquiry. No, this doesn’t hold true for CBD. The best thing to do is to start low and slowly increase the dose gradually, only if needed. You want to find your personal sweet spot dose with CBD. One easy way to do that is to start out with the serving size listed on the bottle and go from there. Let me know if you have more questions and I will do my best to help 🙂
American veterans have been vocal in the discourse regarding medical marijuana. Scientists found that people with Post Traumatic Stress Disorder (PTSD) are deficient in endocannabinoids. They also found that CB1 receptors signal the deactivation of traumatic memories. PTSD is increasingly popping up on states’ lists of qualifying conditions for medical marijuana. In June 2017, Colorado added PTSD to its list making it the ninth and most recent qualifying condition. New York added PTSD to its tightly controlled program this year after pressure from veterans groups made its way to the governor. Those affected by PTSD often suffer from extreme anxiety, drastically impacting their life and ability to interact with others.
Taking CBD oil is like drinking milk and calling it calcium, Hernandez said: There’s some in there, but at very low concentrations dispersed among a host of other ingredients. And what those other ingredients are is anyone’s guess. “The thing to know is that CBD hasn’t gone through the safety controls, the efficacy controls that we usually use, the clinical trials,” Hernandez said. “The jury is still out regarding how safe this drug is.”
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.

So far, though, there’s scant clinical evidence for the claimed benefits of CBD. In June, the Food and Drug Administration approved the first CBD drug, Epidiolex, for treating seizures associated with two rare forms of epilepsy. Otherwise, the FDA doesn’t consider CBD products to be dietary supplements—manufacturers can’t claim the products will diagnose, treat, or cure any diseases. Instead, CBD product literature contains phrases like “restore vitality,” “relax and recover,” and “may keep healthy people healthy.”
Saw this comment and had to answer. Especially as I get asked this quite frequently. Generally speaking there are dozens of CBD oils on the market. It’s important to go for one that uses a good extraction process (CO2 is preferred) and a brand that has a good reputation. From a medical point of view we are still not 100% sure of the effects but we know that CBD has fewer side effects than opioids or other anti-inflammatory drugs. It’s important though to consult with your primary physician before using any sort of medication.
People claim that cannabis oil can be used to treat a wide range of conditions, though evidence to back up these claims is often lacking. For example, according to Medical News Today, people use cannabis oil for conditions ranging from pain to acne; some even claim the oil can cure diseases like Alzheimer's and cancer. (But again, there is no clinical evidence to support these claims.) 

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