The interesting thing about CBD and sleep is that in small to medium doses, CBD is mildly alerting – stimulating the same receptors as caffeine. However, several patients with insomnia report that consuming CBD oil (in tincture or extract form) a few hours before bed leads to a great night’s sleep. So why do the anecdotal results contradict the reported medical studies? 
When the title of Best CBD Hemp Oil was up for grabs, it’s little wonder the renowned Charlotte’s Web Hemp Extract from CW Hemp took the crown with room to spare. This potent and clean hemp oil extract has earned itself a remarkable reputation over the years, and the handy and discreet tincture is the ideal way to sample its soothing benefits for yourself.
One of the main reasons behind not getting enough sleep is said to be the inability to turn your mind off at night. It would seem that as soon as you lay your head down to sleep, thoughts from the day catch up to you and invade any chance of peace you may have sought in sleep. This may be due to a great number of different things, but most often is due to an overactive mind, stress and even anxiety.

Results from the study indicated that CBD administration increased neuronal proliferation and neurogenesis in the hippocampal region.  It is also thought that CBD’s modest affinity for cannabinoid receptors CB1 and CB2 may contribute to hippocampal neurogenesis.  Stimulation of the CB1/CB2 receptor sites upregulates endocannabinoid signaling and leads to neuronal growth.
People with specific phobias experinence strong, irrational fears of certain objects, places, or situations (fear of snakes, flying, big spaces, small spaces, etc.). These phobias can disrupt daily routines and limit a persons abilities to function properly. Some phobias develop in childhood, while others in adolescence or early adulthood. 19 million, 8.7% of the US population suffer from specific phobias. Women are twice as likely to be affected as men.
Yet the DEA has stated unequivocally that it considers CBD to be illegal under the Controlled Substances Act. “CBD derived from the cannabis plant is controlled under Schedule I of the CSA because it is a naturally occurring constituent of marijuana,” Joseph Rannazzisi, the deputy assistant administrator of the DEA, told a congressional panel in June. “While there is ongoing research into a potential medical use of CBD, at this time, CBD has no currently accepted medical use in the USA.” Moreover, DEA spokesman Eduardo Chavez told the New Republic that Medical Marijuana, Inc.’s in-house opinion with regards to CBD has no merit. “The bottom line,” Chavez said, “is the oil is part of the marijuana plant, and the marijuana plant is currently a Schedule I controlled substance under federal law.”

Hey Michael. Thanks for your question. The mg per drop of CBD oil will vary depending on the brand and concentration. Usually it will tell you on the label how many mgs of CBD per drop. Regarding how much you should take for sleep – this is usually going to vary for each person but a good place to start is with the serving size on the label of the CBD product you are using. Please let me know how else I can help and I’ll do my best 🙂


This is a topic I am asked about all the time, and have been for years: how does cannabis help sleep and health? I’ve heard that the number-two reason why people smoke or use cannabis is for sleep. Considering the recent passing of the recreational use of cannabis in California and other several states I think it is high time (pun intended!) to look at CBD, one of the most active ingredients in medical cannabis.
Hi. I really do believe it depends on the mg & ratio of the CBD to THC. My first try at high CBD : low THC tincture oil was with Humboldt Anthropology 16:1. I started off with 2 drops twice a day after 3 days I went to 4 drops twice a day. After a few daysof that I went up to 6 drops and then 8 drops and then 10 drops twice a day. 10 drops twice a day was a perfect dosage for me. FINALLY no pondering worries or fears from all the “what if’s”. If I didn’t want to think about something I had control over not thinking about it. It was an amazing feeling. It was complete FREEDOM. Sadly the dispensary I use no longer has the Humboldt Anthropology 16:1 tincture. Last week I moved on to my first trial with a different brand. They recommend Jayden Juice 28:1 tincture 2 to 3 drops twice a day. Very 1st dose tried 4 drops(because I was up to 10 with my other tincture) and felt weird. Kinda spaced or like a head change. Not sure if it was my tincture or the fear (my anxiety) of trying something different. Didn’t like that feeling one bit. My second dose for the day I took 2 drops. With that said I took 2 drops twice a day for a couple of days. I could feel the anxiety stirring around within me. That warm tingling feeling in my chest and arms. All the “what if” thoughts are far off in the back ground of my mind. Crazy thing because I haven’t felt that feeling in over a year while taking Humboldt Anthropology 16:1 even after the passing of our son this past Aug. As of yesterday I started 3 drops twice a day with the Jayden Juice 28:1 that I currently have. Praying that I can make this work for me. $80 for .05 oz is a tad pricey, “what if” it doesn’t work for me.
I decided to try CBD when I was withdrawing from Tramadol, a synthetic opiate I had been taking for pain (with 2 other medications) for over a year. As I began slowly reducing my use, I experienced a lot of anxiety and muscle tremors in my legs especially. I know that using a marijuana medication meant that my pain doctor would not prescribe for me again, but I was getting off the pain medications one by one anyway, so I don't care.

Authors noted that CBD is capable of reducing anxiety, panic, and obsessive tendencies.  It appears to reduce autonomic arousal and conditioned fear expression, and impairs anxiogenic effects associated with stress.  What’s more, it enhances fear extinction and appears to induce a blockade of traumatic memory “reconsolidation”– reducing the frequency at which persistent traumatic memories resurface.


Ganja is simply around us more, its unmistakable but increasingly unremarkable smell hanging in the air. Yes, smoking it may lead to temporary laughing sickness, intense shoe-gazing, amnesia about what happened two seconds ago, and a ravenous yearning for Cheez Doodles. Though there’s never been a death reported from an overdose, marijuana—especially today’s stout iterations—is also a powerful and in some circumstances harmful drug.


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Michael earned an MBA from the University of Windsor’s Odette School of Business in 2009 and an M.D. from Schulich School of Medicine at Western University in 2013, before entering a Family Practice residency at the University of Toronto. A member of the Canadian Consortium for the Investigation of Cannabinoids, Doctors for Responsible Access and the Canadian Pain Society, he has completed over 2,000 cannabinoid therapy consultations and has presented many talks in community and hospital settings while serving as student health physician at Seneca College and Medical Director, Canabo Medical Clinic.
CBD = cannabidiol; HV = healthy controls; DBP = double-blind placebo; SAD = social anxiety disorder; HC = healthy controls; SPECT = single-photo emission computed tomography; rCBF = regional cerebral blood flow; fMRI = functional magnetic resonance imaging; HPC = hippocampus; HYP = hypothalamus; PHG = parahippocampal gyrus; STG = superior temporal gyrus; MTG = medial temporal gyrus; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex
Dr. Ethan Russo, medical director at Phytecs, a biotechnology company spearheading research into plant- based medicines and the endocannabinoid system, took issue with Titus’s claim, however. “Bioaccumulators can recruit heavy metals from the soil,” Russo said, “but breaking them down would be alchemy.” Government regulation of the pharmaceutical industry is designed to protect consumers from unfounded scientific claims.

I’ve been on anti-depressants for 11 years since having a stroke and having to stop taking estrogen. I started on Zoloft, then celexa, then Effexor. I’ve been having bad blurry vision for a few years that has my eye dr stumped. Finally my primary doctor thought it could be the Effexor since that is one of the side effects. So we decided that I would wean off the Effexor and try Wellbutrin instead. I lowered the amount of Effexor over 3 weeks till I wasn’t taking it any longer but started the Wellbutrin the last week of taking Effexor. After 3 days of no Effexor the withdrawals seemed to hit me. Headaches, nausea, extremely emotional, and bad dizziness. I had an important event to go to on day 3 of no Effexor so I took a low dose (37.5 mg) hoping to get me through the night. I felt decent for a couple days then boom, the withdrawal symptoms came on fully again. So I decided I would just try to go off both the Effexor and Wellbutrin because I didn’t want to go through this again and really wanted to see if I could handle life without them. Well it’s been a week without any Effexor but the dizziness and emotional outrages are still going on. I’ve been using Bonine (motion sickness) which does seem to help a little. My daughter mentioned the CBD oil which I was totally against at first but after doing a lot of research I am now quite interested in it.
In his office, however, Hernandez was wary of the CBD boom. He advises well-meaning parents to think twice about voyaging into the world of over-the-counter hemp oil treatments, even if their circumstances are dire. “It’s a huge gimmick that a lot of companies are using,” Hernandez said. “You don’t know what you’re getting. ... There’s a major quality problem.”
CBD oil products can be somewhat expensive, which may be a barrier for individuals seeking treatment or relief from different conditions and disorders. Endoca is a notable exception as far as price-point is concerned. The brand offers two options for CBD oil: pure CBD; and RAW hemp oil that contains both CBD and cannabidiolic acid (CBDa). These oils are priced at $31 for 300mg oils and $129 for 1,500mg oils; both price-points are significantly below average.

“The week before we tried it, we had 64 seizures,” Penny told me, noting those were only the visible seizures, while unseen neurological events would likely push the number into the hundreds. “We administered hemp oil, and the next week we logged in 28 seizures. ... The very next week, her second week on the hemp oil, we logged none.” Penny paused and repeated herself, as though she could still only half believe the miracle: “None.”
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.

Although most states restrict the use of CBD products to certain medical conditions, manufacturers of CBD claim their products are derived from industrial hemp, and therefore legal for anyone to use.[67] A number of these manufacturers ship CBD products to all 50 states, which the federal government has so far not intervened in.[68][69] CBD is also openly sold in head shops, health food stores, chiropractor clinics, optometrist offices, doctors offices and pharmacies in some states where such sales have not been explicitly legalized.[67][70]
Hi Lauren I've just started today with 250mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well. Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve. Thank you Lyn
Anti-inflammatory: Many individuals with neuropsychiatric disorders have severe inflammation, particularly neuroinflammation. Neuroinflammation is associated with many causative underpinnings including: air pollution, brain injuries, viruses, and even standard aging.  This increase in inflammation can lead to glial cell and cytokine abnormalities, each of which could contribute to anxiety disorders.  CBD has been shown to reduce neuroinflammation, which in turn may directly improve anxiety, as well as cognitive function and mood.
Cannabis has been used medicinally for centuries, as a sleep aid, a pain and nausea reducer, to relieve anxiety and other mood problems. In the mid-1960s, scientists identified the first cannabinoid. Since then, scientists have gone on to identify more than 80 individual cannabinoids and continue to investigate them for their potential symptom-relieving and disease-fighting abilities.
Interactions: CBD, especially when ingested at high doses, may interact with other pharmacological agents, including prescription drugs. Cannabidiol inhibits CYP450 isoenzymes in the liver which means it may be contraindicated with drugs like Warfarin.  Researchers should attempt to understand the full-spectrum of CBD interactions and refine usage guidelines for those taking other medications.
Hey Frank. Indeed there is some exciting research on the effect of CBD on serotonin related receptors. I completely understand why you want to know the ideal dose to take for this purpose. However, it’s not possible for me to provide dosing recommendations. Most people start off by taking the serving size listed on the CBD product they are using. From there, they either decrease or gradually increase the dose as needed. I know that’s not a specific answer but I hope it helps a little. Let me know how I can be of more help and I will do my best 🙂
For instance, some people report a sense of calm and peace; others report increased anxiety levels and unpleasant sensations. The intensity of these symptoms will largely depend on an individual’s body composition. In addition, marijuana strains feature different levels of oil concentration that also determines the intensity of the outcomes that a user feels after consumption. Some strains are recommended to produce less profound symptoms and reactions.
A study conducted by Martin-Santos et al. (2012) aimed to compare the acute effects of two notable cannabinoids: CBD (cannabidiol) and THC (tetrahydrocannabinol).  Researchers recruited 16 healthy males and set up a randomized, placebo-controlled, double-blind, cross-over trial.  The 16 participants received three consecutive single-dose agents administered 1-month apart in the following order: 10 mg THC (oral) – first month, 600 mg CBD (oral) – second month, or a placebo – third month.
Each and every bottle is grown and processed with the same standards as the last guaranteeing quality and assuring potency. Made from CBD rich hemp flower sun grown in Oregon and MCT oil, Rosebud is proud to be a Vegan, Gluten Free, Non-GMO, Organic, and Sustainably Processed CO2 extract. Choose between our three potencies: 350mg, 700mg and 1000mg. 
Endocannabinoids (ECS), a group of endogenous cannabinoid receptors that play a key role in memory, mood, brain reward systems, drug addiction, and energy balance. They are also known as »the body’s own cannabinoid system«. Research shows the benefits of the ECS system in fighting depression, anxiety, increasing appetite, and creating feelings of well-being. CBD naturally acts on the ECS system’s signals to increase receptor function and flow. CBD, along with 2-Arachidonoylglycerol(2-AG), is involved in the regulation of appetite, immune system functions and pain management.
I felt the same way. I had anxiety about taking CBD Oil. I have never used it before and of course, I have never even used marijuana. I was nervous that it had .3 THC in it. My husband had to keep reassuring me that it was okay for me to take. I’m as straight-laced as they come. I have an extreme type A personality. I tried it. It made me feel light headed and very sleepy. I took my second dose this morning. I honestly can’t tell that it is working. I haven’t yelled at anyone so maybe it is lol. I’ll keep taking it about maybe once a day. I don’t know about twice a day. It again, still makes me feel a tad tired. I have to function. I hope it works and is not all hype.
Sample sizes: As was already mentioned, the sample sizes used to test the effects of CBD for anxiety were relatively small-scale. Although the results from these small-scale studies may be accurate, larger-scale trials (with larger sample sizes) are warranted to confirm preliminary outcomes.  A therapeutic effect found in just 10-20 patients may not hold up in a group of several hundred.

Though unflavored and priced higher than competitors, Green Roads CBD oils are made by a trusted manufacturer and use organically grown hemp. Following the CO2 supercritical fluid extraction process, board-certified pharmacists formulate the tincture by hand. Green Roads only sells CBD isolates, so if you’re looking for broad-spectrum products look to some of our other recommendations.
Based on the existing scientific literature, it is impossible to conclude whether CBD is therapeutically effective as a treatment for anxiety disorders – especially when administered chronically and/or over a long-term.  However, considerable evidence supports the efficacy of CBD when administered acutely for: social phobia, public speaking anxiety, and environmental stress.  Acute administration of CBD appears to improve subjective, physiological, and objective measures of anxiety in stressful situations.
Hi Eric, sorry to hear you are suffering. In regards to the oils, i am no doctor and tried a few before i found what works best for me. I think it depends on your condition and genetics. For example, I use green roads and it is extremely effective, but it doesn’t work for my wife. I think you have to find the one that works for you. Maybe someone else can who has more experience can also help.
CBD is available in oils, or it can be added to creams, ointments and beauty products. It can also be used in a vape pen or even consumed through food like CBD gummies. Joel Greengrass, CEO of Theramu, a company that creates non-THC CBD oil, said he has observed a huge increase in interest and popularity of CBD for skin and wellness complaints, as well as for the treatment of a range of anxiety conditions.

Wondering where to buy cannabis oil? Look for a reputable company that sells its products legally (according to your specific state laws) with full transparency and accountability. It’s very important to make sure any cannabis oil you purchase has been tested by accredited laboratories to ensure that is is free of pesticides, residual solvents (from the extraction process), bacteria, fungus, foreign matter and heavy metals.
Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid.[42] In strongly basic media and the presence of air, it is oxidized to a quinone.[43] Under acidic conditions it cyclizes to THC.[44] The synthesis of cannabidiol has been accomplished by several research groups.[45][46][47]
Fear and anxiety are adaptive responses essential to coping with threats to survival. Yet excessive or persistent fear may be maladaptive, leading to disability. Symptoms arising from excessive fear and anxiety occur in a number of neuropsychiatric disorders, including generalized anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and obsessive–compulsive disorder (OCD). Notably, PTSD and OCD are no longer classified as anxiety disorders in the recent revision of the Diagnostic and Statistical Manual of Mental Disorders-5; however, excessive anxiety is central to the symptomatology of both disorders. These anxiety-related disorders are associated with a diminished sense of well-being, elevated rates of unemployment and relationship breakdown, and elevated suicide risk [1–3]. Together, they have a lifetime prevalence in the USA of 29 % [4], the highest of any mental disorder, and constitute an immense social and economic burden [5, 6].
CBD inhibited escape responses in the ETM and increased DPAG escape electrical threshold [68], both proposed models of panic attacks [95]. These effects partially depended on 5-HT1AR activation but were not affected by CB1R blockade. CBD was also panicolytic in the predator–prey model, which assesses explosive escape and defensive immobility in response to a boa constrictor snake, also partially via 5-HT1AR activation; however, more consistent with an anxiogenic effect, CBD was also noted to decrease time spent outside the burrow and increase defensive attention (not shown in Table ​Table1)1) [75, 86] . Finally, CBD, partially via CB1Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [89]. Anticompulsive effects of CBD were investigated in marble-burying behavior, conceptualized to model OCD [96]. Acute systemic CBD reduced marble-burying behavior for up to 7 days, with no attenuation in effect up to high (120 mg/kg) doses, and effect shown to depend on CB1Rs but not 5-HT1ARs [71, 74, 88].
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While most of the studies have only been conducted on lab rats, (which, by the way, we have the government to thank for listing cannabis as a Schedule 1 drug, meaning virtually no human studies are permitted), the information that has been presented thus far has in large part been promising, although it is still inconclusive as to whether or not CBD really does act as a “miracle” sleeping pill.
The vast majority of CBD oils come in bottles measuring either 15 milliliters (mL), or 0.5 ounces; or 30 mL, or 1 ounce. However, CBD concentration is more important than bottle size. Concentration refers to the ratio of hemp oil solution (measured in mL) compared to the amount of CBD cannabinoid (measured in milligrams, or mg). A 15-mL bottle may contain 100 mg of CBD, 300 mg, 500 mg, or more. The higher the mg amount, the stronger the CBD oil will be. For this reason, the ‘mg’ measurement is also referred to as the oil’s strength; i.e., 400-mg oil might be called 400-strength oil.
For most people with epilepsy, diagnosis sets off a gauntlet of trial-and-error attempts to find the right medication. The process is tortuous, with seizures alternately dying down and flaring up while side effects— fatigue, nausea, liver damage, and more—develop without warning. This is partly due to the fact that “epilepsy” is actually a broad category that includes a number of distinct seizure disorders. About 30 medications approved by the U.S. Food and Drug Administration are currently used to treat these conditions, and when a person first begins having seizures, there is often much tinkering with combinations and dosages. I spent years battling side effects like vomiting, dizziness, drowsiness, and severe headaches, which were alleviated only by yet another prescription medication. Parents who endure enough sleepless nights caring for a sick child can become desperate for a cure.
Further testing found what the world now knows: This compound is the plant’s principal active ingredient, its mind-altering essence—the stuff that makes you high. Mechoulam, along with a colleague, had discovered tetrahydrocannabinol (THC). He and his team also elucidated the chemical structure of cannabidiol (CBD), another key ingredient in marijuana, one that has many potential medical uses but no psychoactive effect on humans.
Hemp oil — obtained by pressing benefit-rich hemp seeds — is slightly different than cannabis oil, although they both come from the same genus, Cannabis, and the same species, Cannabis Sativa. The term hemp is used to describe a Cannabis Sativa plant that contains only trace amounts of THC. Hemp is a high-growing plant that’s commonly grown for industrial uses, such as oils and topical ointments, as well as fiber for clothing, construction, paper and more.
Pharmaceutical companies producing oils are subject to a pharmaceutical production licence for controlled drugs, issued by government regulators. Currently there are no pharmaceutical companies producing cannabis oil as a medicine. This might change in the future when a standardised, GMP-certified production method becomes available, setting the standards for the production of cannabis oil as a pharmaceutical product.

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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