You may be familiar with a concept called the entourage effect. The entourage effect states that cannabinoids work better together than they do alone. In essence, CBD is more effective when combined with other cannabinoids like CBG, CBN, THC, and so on than it is in isolation. The terms “full-spectrum” and “whole-plant” are alluding to this concept. Biologically, a person gets high by having THC bind to CB1 receptors in the brain. CBD also binds to CB1 receptors in the brain and has been shown to actually counteract some of the effects of getting high by blocking the activation of THC in CB1 receptors. CBD changes the shape of the receptor so that there is less room for THC to bind to. CBD has even been shown to decrease the heightened heart rate that you feel from getting high. Therefore CBD can even have an impact on the anxiety that comes from the psychoactive effects of THC.


I woke up seriously looking forward to my morning CBD oil fix … I mean, tonic. Truth be told, I’m an anxious person. Although I do a lot to try and calm my nerves, sometimes anxiety gets the best of me. But regardless of emotional or physical stress (I’m training for a marathon and running quite a bit!) I experienced this week, I felt a lot more in control after drinking my CBD oil tonics.  After work, I met up with a friend and felt like I could fully focus on our conversation without distractions. Could it be the CBD?
@parus i just got my certification for medical marijuana. Upon buying what was recommended I was given CBD oil, I’ve not been on it a week yet today will be my fourth day of using it. It takes about 1/2 hour to work but it seems to help. They also gave me a cannabinol patch to use at night fir the severe itch in my head from the shingles. Also a vape two puffs as needed for the itch break through which I have not tried yet. I’m a bit anxious about using it.
Hippocampal neurogenesis: One hypothesized mechanism by which pharmaceutical anxiolytics may decrease anxiety is via hippocampal neurogenesis – or growth of new neurons within the hippocampus.  It appears as though cannabidiol administration induces hippocampal neurogenesis in animal models, and for this reason, similar outcomes may occur in humans.  A rat study involving the chronic administration of 5-HT1A partial agonist (tandospirone) increases the biomarker of doublecortin – indicating emergence of new neurons in the hippocampus.
Hello Roy,We will attempt to help you as much as possible.As you know CBD is a new treatment option so there are almost no scientific studies and very few case studies available. However as a general rule the best thing to do is just to start.We say this because everyones body metabolizes CBD at different rates. So the best way to find the proper dosage for you is just to start. The good news is that feeling sleepy is about the only side effect of overdosing CBD, so experimentation is pretty safe.What we recommend on our site is to start with 25mg of CBD taken as often as you need it throughout the day. If you find this works stick with it. If you find you need more, or are having to take it too many times during the day, then take more such as 50mg with each serving.Which oil should you use that will ship to the UK? We have reviewed all the top CBD oil products and have found Endoca to be the best and most powerful oil on the market. If you are going to use CBD hemp oil we recommend using raw CBD oil. This is the most natural and has the highest amount of plant constituents present which increases effectiveness.The best oil to start with is Endoca Raw Hemp Oil 2000mg. If taking 50mg a day this tube will last you 40 days. If you are taking 200mg a day you will need to purchase 3 tubes per month.Read the full review here: https://cbdoilreview.org/endoca-raw-hemp-oil-2000mg/Buy the product here: https://cbdoilreview.org/product/endoca-raw-hemp-oil-2000mg/Endoca ships to the UK from their European headquarters so you are good to go there. If you have any other questions please contact us using the form below or give us a call, we are happy to help!

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Basically, CBD is a 100% natural chemical that’s found in the marijuana plant. It is what’s referred to as a “phytocannabinoid,” which means it belongs to a class of molecules that interact with endocannabinoid receptors in the human body. These receptors belong to the body’s endocannabinoid system, or ECS, which is responsible for essentially all of our homeostatic functions.
"Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia.
For instance, some people report a sense of calm and peace; others report increased anxiety levels and unpleasant sensations. The intensity of these symptoms will largely depend on an individual’s body composition. In addition, marijuana strains feature different levels of oil concentration that also determines the intensity of the outcomes that a user feels after consumption. Some strains are recommended to produce less profound symptoms and reactions.

Hi Celeste. Thanks for your question. I would say as long as you feel comfortable with it, you can increase the dose for sleep to see if it has a stronger effect on your insomnia. You can carefully increase the dosage by another half or full dropper-full and see if that helps. In regard to how much to take during the day, how much are you currently using during the day?
If you are suffering from pain which is preventing you from having a good nights sleep, then CBD Essence may be the solution. CBD essence has quite a unique extraction process which involves state-of-the-art technology and high-grade hemp that goes through some of the most rigorous testing. This allows them to produce a product that is rich in hemp extract, and contains several key ingredients found in the Cannabis plant.
Ally has been helping people since High School. Today she is married, mother of 4 wonderful children and an entrepreneur. She's the leading force behind CuredByNature.org website as and a Premium CBD brand PAPILO. She loves taking pictures and taking family trips. She's passionate about natural ways to heal our body and mind. Ally's dream is to help people "wake up".
I started taking 100 mg cbd a month ago (2-3 drops at night every other day) I had a eye twitch and stayed up late doing homework and on my phone but was able to sleep fine. A few weeks ago I started increasing my dosage. 4-5 drop before bedtime every night (though my eye twitching is gone) the past two weeks I have been suffering from horrible insomnia/anxiety/depression/loss of appetite. Could CBD not be for me? Am I not taking enough? Can the low dosage I am taking be stimulating my nervous system keeping me up at night? help.
I have had several neurological conditions like Bells Palsy three times, double vision, paralysis of left side of tongue. I have a lot of relief whenever I have pain by taking an inflamattory drug etoshine90 mg. Presently I have started taking Steroids for my facial palsy. The various pains I was having on the left side of neck, below the left ear, dizziness, pain around the head have subsided immidiately after the first dose of prendisolone 60 mg.I have read that CBD hemp oil can be useful for my condition of neurological and inflammation issues. My question is what concentrate (mg) of the oil should I take and for how long. Any brand that you may suggest that are available in the UK. Thank you.
People claim that cannabis oil can be used to treat a wide range of conditions, though evidence to back up these claims is often lacking. For example, according to Medical News Today, people use cannabis oil for conditions ranging from pain to acne; some even claim the oil can cure diseases like Alzheimer's and cancer. (But again, there is no clinical evidence to support these claims.) 

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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