Hash oil or cannabis oil is an oleoresin obtained by the extraction of cannabis or hashish. It is a concentrated form of the plant containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids. There are a variety of extraction methods, but most involve a solvent such as butane or ethanol. Hash oil is usually consumed by smoking, vaporizing or eating but sometimes other methods are employed. Hash oil is sometimes sold in cartridges to be used with pen vaporizers.
Evidence indicates that CBD is an effective intervention for neuropsychiatric anxiety disorders such as: generalized anxiety disorder, social phobia, panic disorder, PTSD, and OCD.  Researchers believe that its anxiolytic effects are principally a result of its affinity for 5-HT1A and CB1 receptors.  While further research is warranted regarding long-term use of CBD oil for anxiety, authors note that it does not increase anxiety, has minimal sedation, and is extremely safe when used over a short-term.

my mom is 61 years old, actually got her to try CBD oil for anxiety and she’s actually been using it for months hahah. Does not have a medical marijuana card (lives in FL), but bought her the purekana 1,000 mL and sometimes she’ll go over a week without having to take her Xanax or sleep med prescription. amazing stuff I really hope CBD oil gets its due credit soon and more doctors start prescribing
“These studies mainly point to CBD’s ability to interact with ... serotonin receptors and GABA receptors in the brain,” she explained. “Serotonin plays an important role in mood and anxiety, and GABA is known as the main ‘inhibitory’ neurotransmitter, meaning it calms excess activity in the brain and promotes relaxation. GABA receptors are the target of benzodiazepines, which are a class of anti-anxiety drugs.”
Here’s my experience: started with insomnia in 2011 that led up to a vicious circle insomnia/anxiety/depression. Took all kinds of sleeping pills/benzodiazepines for around 3-4 years straight until I decided to stop. Yoga, meditation, binaural beats, smoking pot, you name it. I started reading about CBD like 2 months ago and decided to give it a try. I live in Europe so I was able to get my hands in a product that’s a mix of CBD and melatonin. So far it has been working great if I take it after exercising for around 1 hour at the gym. It works well but in moments of high stress it has no effects at all. As soon as I get worried about anything, or if I get sick I’m not able to sleep at all even if I take the whole bottle of CBD oil, I honestly don’t know why, I guess it’s very “mental” but in general I sleep very well after taking CBD oil.

Similarly, though CBD oil is technically illegal on the federal level, it is sold freely online and in stores even here in New Jersey. Erica McBride, executive director of the National Hemp Association in Washington, said there have been instances in states where pot hasn't been legalized where CBD oil was confiscated at the post office or people possessing it were arrested, but it's “very rare.”
Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.
From our personal experience, we can also confirm that CBD can have a very calming effect. We can as well imagine that it can help with anxiety, although we do not suffer from anxiety. When I was stressed out by pressure, it always helped a lot. This may not exactly be anxiety in the real sense of it, but the potential could already be guessed well.
A bit of online digging led me to realize that the active ingredient in Charlotte's Web Everyday Plus Hemp Oil, the product I'd been offered to test, was the chemical compound CBD, which stands for Cannabidiol. Unlike THC, the other crucial compound in hemp and marijuana plants, CBD does not produce the psychoactive effects that make you feel "high"; instead, it actually eases anxiety and makes you less likely to freak out.
Increased anxiety: Rodents administered cannabidiol daily for 14 days exhibited anxiogenic behaviors. In other words, the cannabidiol may increase anxiety when used too regularly.  Although this effect cannot be confirmed in humans, it is logical to assume that a person’s neurophysiology will adapt to the effects of CBD when used regularly, possibly blunting its efficacy.
Like Elixinol, CBD Essence has been around for quite a few years and they definitely know a thing or two about hemp oil. The owner Don has actually been around the pharmaceutical industry for some years, and therefore knows how to deliver a quality and effective product. All of their oils are created using CO2 extraction methods, which have been known to be safer and more effective than solvent-based extraction. They avoid CBD isolates, and they always disclose lab test results to ensure there are no heavy metals or contaminants in the oil.
Hi, I have had spondylolisthesis since age 11 which left me with extreme nerve pain...restless leg syndrome. Had 3 spinal ops and also had hip surgery 2 years ago. have asthma and hypothyroidism. I can deal with everything else but this nerve pain is insane. Used Gabapentin for 9 years and now its not in the market in Nairobi, Kenya where I live. Am on Lyrica, which is not working. I started Cbd oil in August but now found my body has become immune to the effects of pain releif I was getting. Can anyone suggest what strength oil/cbd supplement I should aim for? Currently am making flapjacks with weed, have one every night but this makes me high which I dont want. I still wake up in pain at night, please help.
CBD inhibited escape responses in the ETM and increased DPAG escape electrical threshold [68], both proposed models of panic attacks [95]. These effects partially depended on 5-HT1AR activation but were not affected by CB1R blockade. CBD was also panicolytic in the predator–prey model, which assesses explosive escape and defensive immobility in response to a boa constrictor snake, also partially via 5-HT1AR activation; however, more consistent with an anxiogenic effect, CBD was also noted to decrease time spent outside the burrow and increase defensive attention (not shown in Table ​Table1)1) [75, 86] . Finally, CBD, partially via CB1Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [89]. Anticompulsive effects of CBD were investigated in marble-burying behavior, conceptualized to model OCD [96]. Acute systemic CBD reduced marble-burying behavior for up to 7 days, with no attenuation in effect up to high (120 mg/kg) doses, and effect shown to depend on CB1Rs but not 5-HT1ARs [71, 74, 88].
The exclusion criteria for the trial were: (i) presence of organic brain syndromes; (ii) use of psychoactive drugs, including nicotine; (iii) presence of general medical conditions, assessed by the patient’s report during the interview and/or through physical examination; (iv) presence of psychiatric disorders (assessed with the SCID-IV); (v) pregnancy; (vi) previous history of any sleep disorder (based on the Pittsburgh Sleep Quality Index - PSQI); and (vii) recent changes in sleep time (variation of more than 2 h in the last 7 days, measured through the sleep log). Thus, the volunteers were all non-smokers and had not taken any medications for at least 3 months before the study. Moreover, none of them had used marijuana more than five times in their lives (no use in the last year) and none had ever used any other illegal drug. All subjects gave their written consent to participate after being fully informed about the research procedures, which were approved by the Hospital das Clínicas de Ribeirão Preto of University of São Paulo ethics committee (HCRP No. 17912/2013).

I felt like many other users – afraid and nervous to take a dose of something that is supposed to take away my nervousness and anxiety. I use PureKana Vanilla 300mg. I’ve used it off and on for about a month. I started with 3-4 drops to get my body use to it and I noticed that the first night I tried it I ended up sitting on the couch watching t.v. not thinking about whether or not I was feeling ok – I just was. My bf asked how I was feeling and I was just feeling good – normal – calm. The next time, I took 4 – 6 drops but my anxiety overpowered the oil. I was going into a stressful work situation and even though I tried to attack the issue before I thought it would happen I ended up having an anxiety attack until I removed myself from the loud crowd and sat in nature with quietness. It was very discouraging at that point. I decided to give it a break and a week later I felt my stomach butterflies and ‘off’ feeling happening. I took 6 drops and sat outside where I was comfortable with a book and water. I ended up feeling fine and my anxiety just melted away without me realizing it. I think cbd oil is a great natural way to treat anxiety but go into it open-minded. It may work right away but sometimes the situation could outweigh the small dose and you just need more for a more stressful situation. I still believe in the power of the plant. It was put on this earth for a reason – to help!
No statistically significant differences were found between groups in the VAMS, STAI, Digit Symbol Substitution and Symbol Copying Tests, and PVT. In the analysis of the WAIS, the results in the Symbol Copying Tests showed no effects of drug (F1,24 = 2.46; p > 0.05) or order of administration (F1,24 = 0.44; p > 0.05), but the interaction between drug and order was significant (F1,24 = 4.9, p < 0.05). To check if this interaction could have potentially interfered with the results, we split the subjects, comparing the placebo and CBD groups separately in the two orders (first placebo or CBD). Again, there was no difference between groups in the two situations.
Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.[71]
Hi Marilyn, I would recommend a topical lotion or salve to start for instant relief.. Maybe 250 to 300 mg tincture to see how you feel. For me, the salve took the pain in my hands away in under a minute. I didn't notice how much the tincture worked until I forgot to take on vacation. Pain that was pretty much gone but came back, I was tired, grumpy and felt horrible. It works, just need to find right product and dosage for you.
Hippocampal neurogenesis: One hypothesized mechanism by which pharmaceutical anxiolytics may decrease anxiety is via hippocampal neurogenesis – or growth of new neurons within the hippocampus.  It appears as though cannabidiol administration induces hippocampal neurogenesis in animal models, and for this reason, similar outcomes may occur in humans.  A rat study involving the chronic administration of 5-HT1A partial agonist (tandospirone) increases the biomarker of doublecortin – indicating emergence of new neurons in the hippocampus.
For people who suffer from insomnia, constant anxiety during the night or simply struggle to get a sound, restful night of undisturbed sleep, cannabis sativa essential oil may work like a charm. However, according to a research report published by Dr. Ethan Russo, Director of Research for the International Cannabis and Cannabinoids Institute, terpenoids produce an “entourage effect”.

All exposure to restraint stress resulted in increased blood pressure and heart rate, thereby significantly increasing anxiety in the elevated plus-maze 24 hour.  However, administration of CBD alleviated the anxiety associated with the elevated plus-maze.  Prior administration of the 5-HT1A antagonist inhibited the therapeutic effects of the cannabidiol.


While CBD predominantly has acute anxiolytic effects, some species discrepancies are apparent. In addition, effects may be contingent on prior stress and vary according to brain region. A notable contrast between CBD and other agents that target the eCB system, including THC, direct CB1R agonists and FAAH inhibitors, is a lack of anxiogenic effects at a higher dose. Further receptor-specific studies may elucidate the receptor specific basis of this distinct dose response profile. Further studies are also required to establish the efficacy of CBD when administered in chronic dosing, as relatively few relevant studies exist, with mixed results, including both anxiolytic and anxiogenic outcomes.

CBD can fight insomnia without making you get high. On the other hand, certain CBD oil formulations that contain low amounts of THC may also be employed for treatment of this condition. This is why it is very important that your doctor approves of your decision about taking CBD oil or edibles for sleeping disorders. Make sure that you are not self-administering yourself with any online treatment.
It also is distinct from THC which acts as a CB1/CB2 partial agonist, thereby stimulating the receptor sites.  If it acted the same as THC at the CB1/CB2 receptor sites, its therapeutic potential may be reduced.  Moreover, since cannabidiol acts as an inverse agonist at the CB1/CB2 receptor sites, it doesn’t induce psychological euphoria and/or pleasure associated with downstream dopaminergic enhancement in the mesolimbic pathway (resulting from CB1/CB2 agonism).

Long-term outcomes: There are zero long-term studies investigating the safety, efficacy, and long-term effects of CBD as a treatment for anxiety. Data from animal model studies suggests that chronic CBD usage could yield deleterious epigenetic and/or neuropsychiatric effects. However, it is unclear as to whether administration of CBD at a normative (non-chronic) frequency would maintain therapeutic efficacy over a long-term.
I’ve been on anti-depressants for 11 years since having a stroke and having to stop taking estrogen. I started on Zoloft, then celexa, then Effexor. I’ve been having bad blurry vision for a few years that has my eye dr stumped. Finally my primary doctor thought it could be the Effexor since that is one of the side effects. So we decided that I would wean off the Effexor and try Wellbutrin instead. I lowered the amount of Effexor over 3 weeks till I wasn’t taking it any longer but started the Wellbutrin the last week of taking Effexor. After 3 days of no Effexor the withdrawals seemed to hit me. Headaches, nausea, extremely emotional, and bad dizziness. I had an important event to go to on day 3 of no Effexor so I took a low dose (37.5 mg) hoping to get me through the night. I felt decent for a couple days then boom, the withdrawal symptoms came on fully again. So I decided I would just try to go off both the Effexor and Wellbutrin because I didn’t want to go through this again and really wanted to see if I could handle life without them. Well it’s been a week without any Effexor but the dizziness and emotional outrages are still going on. I’ve been using Bonine (motion sickness) which does seem to help a little. My daughter mentioned the CBD oil which I was totally against at first but after doing a lot of research I am now quite interested in it.
I have been a member around a year maybe less, but I just need to tell you how much I appreciate you all. I have 3 kids and husband and was crippled with my health problems and drugs from all the doctors, I had to take. I am so much better off today. I can now contribute to my family. I feel hope for the first time for a future with them. Thank you, God Bless You!

The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system (or ECS). The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.
Once I'm asleep, I sleep like I'm dead—I can't be roused by vacuuming, hurricanes, or all three of my morning workout alarms. It's getting to sleep that's the problem. Talk to me all you want about too much blue light and screen time, but even on the nights when I read from a real book, I'm still tossing and turning for at least an hour before I eventually fade out.
My husband was diagnosed with ALS (amyotrophic lateral sclerosis) when he was 61 years old 4 years ago. The Rilutek (riluzole) did very little to help him. The medical team did even less. His decline was rapid and devastating. His arms weakened first, then his hands and legs. Last year, a family friend told us about Rich Herbs Foundation (RHF) and their successful ALS TREATMENT, we visited their website www. richherbsfoundation. com and ordered their ALS/MND Formula, i am happy to report the treatment effectively treated and reversed his Amyotrophic Lateral Sclerosis (ALS), most of the symptoms stopped, he is able to walk and able to ride his treadmill again, he is pretty active now.

The nutrition and supplement industry—which includes CBD products—is almost wholly unregulated. “The concentrations in products are only approximate, and I don’t know how well they’re tracked,” Szaflarski says. Even if you could absolutely trust a product’s label—and many CBD manufacturers, aware of the current scrutiny on their industry, go to great lengths to assure consumers of the quality of their products—there aren’t a lot of concrete facts when it comes to the type or amount of CBD a person should take for a specific ailment or aim.
NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 200 retail locations across the country.
Hey Frank. Indeed there is some exciting research on the effect of CBD on serotonin related receptors. I completely understand why you want to know the ideal dose to take for this purpose. However, it’s not possible for me to provide dosing recommendations. Most people start off by taking the serving size listed on the CBD product they are using. From there, they either decrease or gradually increase the dose as needed. I know that’s not a specific answer but I hope it helps a little. Let me know how I can be of more help and I will do my best 🙂
If I had to rate the efficacy of the second dosing option for anxiety on a scale of 1 to 10, I’d rate it about a 6.  Meaning, it was noticeably more effective than the first low-dose at even just 20 mg.  Perhaps in the future I’ll press my luck with an even greater dose of around 60 mg, which is equivalent to 600 mg CBD and the dosage that has been documented as effective for anxiety in clinical research.
Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.

Further testing found what the world now knows: This compound is the plant’s principal active ingredient, its mind-altering essence—the stuff that makes you high. Mechoulam, along with a colleague, had discovered tetrahydrocannabinol (THC). He and his team also elucidated the chemical structure of cannabidiol (CBD), another key ingredient in marijuana, one that has many potential medical uses but no psychoactive effect on humans.
If you’re like me, I think you’ll agree with me when I say that lack of sleep really interrupts your life. You can become cranky and irritable, snapping at friends and colleagues while your body is screaming for rest. Maybe you’ve gone down the laundry list of “fixes” — meditation, yoga, alcohol, exercise, an electronics detox before bed, you know the drill— but nothing seems to be working. It can be frustrating beyond measure.
Hi, I have had spondylolisthesis since age 11 which left me with extreme nerve pain...restless leg syndrome. Had 3 spinal ops and also had hip surgery 2 years ago. have asthma and hypothyroidism. I can deal with everything else but this nerve pain is insane. Used Gabapentin for 9 years and now its not in the market in Nairobi, Kenya where I live. Am on Lyrica, which is not working. I started Cbd oil in August but now found my body has become immune to the effects of pain releif I was getting. Can anyone suggest what strength oil/cbd supplement I should aim for? Currently am making flapjacks with weed, have one every night but this makes me high which I dont want. I still wake up in pain at night, please help.
“For those patients who have tried and failed with prescription anti-anxiety medications or want another option for other reasons, CBD is a potential alternative with a good safety profile that offers fewer negative side effects and fewer contraindications with other substances,” Pearson said. “While it won’t work for everyone, it offers a gentler alternative that I have seen work for many people.”
Tolerance: It is possible that someone who uses CBD oil often could become tolerant to its effects. This is because no drug is capable of bypassing the endogenous homeostatic mechanisms of the human body.  If something were capable of doing so, people could remain on an anxiolytic and/or antidepressant for an indefinite period of time without any decreased efficacy.  Unfortunately, it is likely that if used too frequently, tolerance will ensue and an individual will require greater doses to maintain a therapeutically anxiolytic effect.
One thing that I really really liked though, was that the effects seemed to last a long time. I have only taken the oil on four separate occasions now, and each time it’s seemed to last like 6-8 hours (or at least all evening). This makes sense too, because after doing a little reading up I found that the sublingual tinctures are much longer-lasting than CBD vape oils or e-juices.
Royal Queen Seeds CBD Oil offers a convenient, discreet and quick way to dose yourself with a bit of CBD, no matter your situation or where you are. All of our CBD oil is created using organically grown hemp sourced from right here in Europe, extracted using the latest CO² techniques. It means our oil is 100% natural, offering pure and strong CBD. All you need to do as drop you dose under your tongue or in your food, and away you go!
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.
Like Elixinol, CBD Essence has been around for quite a few years and they definitely know a thing or two about hemp oil. The owner Don has actually been around the pharmaceutical industry for some years, and therefore knows how to deliver a quality and effective product. All of their oils are created using CO2 extraction methods, which have been known to be safer and more effective than solvent-based extraction. They avoid CBD isolates, and they always disclose lab test results to ensure there are no heavy metals or contaminants in the oil.
Based on reviews, smoking or vaporizing CBD vape oil seems to have less effects when compared to other methods of administering CBD, such as tinctures, capsules and sprays. On the flip side, others argue that smoking or vaporizing has less drawbacks than taking CBD orally, since ingesting CBD orally could result in inconsistent absorption and a delayed effect.
Initial data also suggests that CBD has other far-reaching medical applications. A 2013 study published in the British Journal of Clinical Pharmacology found that “CBD was shown to offer benefits including acting in some experimental models as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent.” This means CBD could be used as “potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.”
Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.

After consulting with Amanda Chantal Bacon of Moon Juice, I decided to invest in a bottle of Gone Green Hemp CBD Oil in the 500mg tincture. Gone Green is a really incredible company that only sources the best herbs, adaptogens, and superfoods, so I knew I would be getting a very high-quality product when I grabbed their bottle off of Moon Juice’s shelf. You can buy Gone Green’s Hemp CBD Oil online—it’s 100% legal in all 50 states. They have the best customer service ever, and they carry tons of other fantastic products that any health-conscious person would love!

It is unclear as to what the optimal dosage of CBD is for anxiety disorders.  Most literature suggests that a single 600 mg dose of CBD is sufficient to alleviate anxiety.  However, the source from which you attain your CBD may make a major difference.  Various companies are selling CBD formatted with nanotechnology and/or co-factors (to maximize bioavailability) and a significantly lesser dose may be required than agents without specialized formatting.


At lower doses, CDB (15 mg/day) co-administered with tetrahydrocannabinol (THC, 15 mg/day) increased wakefulness (Nicholson et al., 2004). More recently, Chagas et al. (2014b) investigated the effects of chronically administered CBD (75–300 mg per day for 6 weeks) in patients with Parkinson’s disease and found a reduction in symptoms of REM sleep behavior disorder. After discontinuation of the drug, the frequency of symptoms returned to baseline levels, prior to treatment with CBD. Finally, CBD-enriched extract was described as a safe treatment for reducing anxiety and improving sleep in a young girl with post-traumatic stress disorder (Shannon and Opila-Lehman, 2016).
Most CBD oils are available in round-number concentrations such as 250mg, 500mg, and 1,000mg. While these strengths accommodate many CBD users, they may not be sufficient for those with preferences that fall outside round numbers. NuLeaf Naturals offers a less conventional selection of concentrations: 240mg, 725mg, 1,450mg, 2,425mg, and 4,850mg. This range ensures that most users will find a strength that works for them.
The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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