A study published in 2008 indicated that CBD injections into the dorsolateral periaqueductal gray area of rats reduced anxiety via 5-HT1A receptor interaction.  Researchers noted that the 5-HT1A receptors were more involved than cannabinoid receptors (e.g. CB1) in reducing anxiety.  The study concluded that cannabidiol interacts directly with 5-HT1A receptors to yield an anxiolytic response.
The oral tincture from 4 Corners Cannabis is our pick for best full spectrum CBD oil. Rather than a tincture infused with heavy flavor, this product contains light hints of coconut and citrus. The result is a pleasant taste that satisfies those who prefer flavored oils, but it is subtle enough to appeal to those who do not liked flavored oils. The tincture is available in 250mg, 500mg, and 1,000mg concentrations. The Avocado Oil Tincture (1,000mg) is another option that is heavier on its flavors, which also include coconut.
Cannabis has been used medicinally for centuries, as a sleep aid, a pain and nausea reducer, to relieve anxiety and other mood problems. In the mid-1960s, scientists identified the first cannabinoid. Since then, scientists have gone on to identify more than 80 individual cannabinoids and continue to investigate them for their potential symptom-relieving and disease-fighting abilities.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!

Two cannabis-based pharmaceutical drugs, manufactured in the UK, are licensed for prescription but only for very specific uses. Sativex has been available in the UK since 2010 and uses THC and CBD to treat spasticity in multiple sclerosis. And a new CBD-only drug, Epidiolex, was approved in June in the US to treat rare childhood epilepsies, with a similar decision expected imminently for Europe and the UK.
After seasonal harvests of specific cultivars, these high-CBD hemp crops are put through a specialized solvent-free extraction process to yield a hemp oil that is naturally high in cannabidiol. This pure hemp extract is then tested for safety, quality, and cannabinoid content before being exported to our processing facilities in the United States. Importing any cannabis or hemp product into the United States is a complicated and serious task, so we leave nothing to chance before our high-CBD hemp oil makes its journey across the Atlantic Ocean.
We are all aware of the promising therapeutic benefits that can be derived from using CBD oil, but it also may interact poorly with other prescription and over-the-counter drug and medications. Since side effects are unavoidable when taking CBD extracted from both hemp and marijuana, its interaction with drugs that are taken simultaneously may result in adverse effects or serious complications. Hemp CBD oil can inhibit the liver’s ability in processing certain medications, which may result in an overall increase in processing times. As the liver experiences difficulty in metabolizing, drugs stay longer in the body. In some cases, the interaction could cause serious side effects or even overdose. With this in mind, you should consult your physician before starting on any hemp CBD oil therapy and may be required to alter your CBD dosage.
Word of Caution: Although this list clearly shows that cannabis essential oil can be an effective remedy for many common health conditions, it is still a potent chemical substance extracted from a plant with psychotropic substances. Therefore, you should always be very careful while using such an essential oil, including the amount you use and the conditions under which you use it. Speak to a professional about mixing essential oils and present medications before adding any new elements to your health regimen. Also, the use of cannabis is restricted/banned in many countries, so consult a local health specialist before use.
Long-term outcomes: There are zero long-term studies investigating the safety, efficacy, and long-term effects of CBD as a treatment for anxiety. Data from animal model studies suggests that chronic CBD usage could yield deleterious epigenetic and/or neuropsychiatric effects. However, it is unclear as to whether administration of CBD at a normative (non-chronic) frequency would maintain therapeutic efficacy over a long-term.
I didn’t use the oil again until maybe about a week later, and I tried the next time around to really gauge when the effects started settling in. I was using the 300 mg bottle (30 mL), which I think is their lowest potency oil (they also had a 600 mg oil and a 1000 mg oil the last time I checked). It seemed to me that I noticed an obvious anxiety relief in less than an hour – maybe about 45 minutes, if I had to take a guess.
And then I woke up on the concrete, a worried crowd gathered around me. “You had a seizure,” my friend said gently as I blinked my eyes, trying to process this new information.  I remember it was warm that night because I was wearing a sundress, and when I finally regained consciousness my first worry was that my dress flew up and everyone could see my underwear.
“I don’t like to take stuff like ibuprofen or prescription medications,” says Andrew Talansky, a professional triathlete from Napa, California, who, as an elite cyclist, rode in the Tour de France. “I’m always looking for natural alternatives.” When Talansky heard an increasing number of athletes talking about CBD, “I went from skepticism to being interested to asking advice on how to use it,” he says.
Typically, pharmaceutical companies making cannabis-based medicines have sought to isolate individual compounds from the plant. But Mechoulam strongly suspects that in some cases those chemicals would work much better in concert with other compounds found in marijuana. He calls this the entourage effect, and it’s just one of the many cannabis mysteries that he says require further study.
Now 13, Jackson — whose diagnosis is undetermined — continues to use marijuana every day. (Like many patients, he ingests it in droplet form, which allows for more precise dosing and avoids lung problems.) He still has seizures, but they are less severe and they occur once every week or two, down from around 200 a month before he started using cannabis. He is back in school full time and is well enough to go on hikes and bike rides with his family.
That grey area is likely to be clarified soon. Key federal legislators are pushing for industrial hemp legalization to be part of the farm bill that will probably pass in the fall of 2018. In terms of athletics, hemp-derived CBD was removed from the World Anti-Doping Agency’s list of prohibited substances earlier this year. Hemp legalization and more companies targeting athletes should further separate CBD from its cultural association with marijuana.
Very detailed and well researched article, thank you. I would like to highlight the possibility of using CBD suppositories as well, since the bioavailability of rectal administration can reportedly reach up to 70%, compared to 6% via oral ingestion or 30% when vaporized. I have even heard of people who produce their own suppositories or simply inject a mixture of CBD and organic edible oils with a syringe. Might not me the most pleasant option, but obviously very efficient.
Subjectively, I’d say it took around 15 to 20 minutes before I noticed some sort of an effect; could’ve been shorter or longer (I didn’t have a timer out).  I wasn’t stressed or anxious prior to taking the capsule, so there may not have been as much neurophysiological contrast.  That said, I noticed that I felt psychologically more relaxed and as if I stopped thinking critically about every little thing.
Food and beverage products containing CBD were introduced in the United States in 2017.[51] Similar to energy drinks and protein bars which may contain vitamin or herbal additives, food and beverage items can be infused with CBD as an alternative means of ingesting the substance.[52] In the United States, numerous products are marketed as containing CBD, but in reality contain little or none.[53] Some companies marketing CBD-infused food products with claims that are similar to the effects of prescription drugs have received warning letters from the Food and Drug Administration for making unsubstantiated health claims.[54]
Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011, February 9). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology, 36(6), 1219-1226. Retrieved from http://www.nature.com/npp/journal/v36/n6/full/npp20116a.html?foxtrotcallback=true
“Strong data is lacking with CBD. There have been only small research trials some showing benefit, others showing no benefit with CBD,” said Pritham Raj, an internist-psychiatrist in Portland, Oregon. “So, in short, the jury is still out. This doesn’t mean CBD doesn’t work for anxiety, it just means that we don’t have enough information to make a strong argument for CBD in the treatment of anxiety.”
The apparatus used for the polysomnography exams consisted of different devices including electroencephalogram with the international 10–20 system (to rule out the occurrence of epileptic seizures), electrooculogram, electromyogram of chin muscles and upper and lower limbs, nasal pressure cannula, oral thermistor, thoracic and abdominal respiratory inductive plethysmography straps, pulse oximetry, electrocardiogram, and snoring and body position sensors. Video and sound were also recorded during the exam.
Hey Linda. Sorry to hear you are struggling with sleep. I know how frustrating this can be. As I’m not a medical professional, I cannot give you advice on dosage for CBD. The Mayo Clinic used to have a dosage guidelines page but they have since taken it down. The dosage they had listed which could potentially help with sleep was 40 mg to 160 mg of CBD. I recommend you let your prescribing physician know you are using CBD alongside the Lunesta.
THC (Tetrahydrocannabinol) Cannabis oil and Cannabidiol (also called CBD) have similarities but some important differences for users. Both cannabinoids, chemical compounds that can be found in all cannabis plants, including hemp and marijuana. Cannabinoids are the substances secreted by the flowers of the cannabis plant and contain natural medicinal properties, offering relief from conditions including anxiety, pain, nausea, and inflammation. There are plant-based cannabinoids and also phytocannabinoids, both with a variety of health benefits.
My friend had told me that all I do was use the dropper bottle and place 15 drops under my tongue, and then wait for about 90 seconds before swallowing (it also says this very clearly on the bottle as well). I actually went in front of a mirror to administer the drops, so I could count exactly how much I was putting in (you really don’t need to do this though because you can kind of feel the drops as they hit your mouth and count how many you’re putting in that way).
My son takes it for adhd. I have a friends child who takes it for autism and lots of testimonials for both issues on my testimonial page. Feel free to reach out to me. I suggest first finding a oil that is full soectrum and ALL ORGANIC! no solvents no chemicals no fillers co2 extraction method. I am in the cannabis industry and this has completely changed my son’s life and others. As well as my own for anxiety.
CBD likewise communicates with a neurotransmitter called GABA (gamma-aminobutyric corrosive). GABA transfers messages from one brain cell, or neuron, to another; that message usually is “Back off” or “stop pushing.” GABA advises the body when it’s a great opportunity to shut down, and since a huge number of neurons in the cerebrum react to GABA, the impacts include lessening anxiety, quieting the sensory system, assisting with rest, unwinding the muscles.
In an initial experiment, the male Wistar rats received injections of CBD and were exposed to 60 minutes of restraint stress – with cardiovascular responses recorded.  In a second experiment designed to determine effects of CBD on the 5-HT1A receptor, researchers administered a 5-HT1A antagonist prior to the CBD.  Precisely 24 hours after CBD administration, the Wistar rats were tested in an elevated plus-maze to gauge anxiety.
Can’t sleep? Cannabis oil also works for people with insomnia. The calming effects of the oil help people to sleep calmly, relieving issues of anxiety and restlessness. A 2015 scientific review published in the American Journal of Health-System Pharmacy found that cannabis treatment is effective for military veterans with post-traumatic stress disorder (PTSD). Research suggests that cannabinoids, the psychoactive components of unrefined cannabis, regulates neurotransmitter release and produces a wide range of central nervous system effects, including increased pleasure and alteration of memory processes.
It should be noted that ipsapirone and CBD may attenuate anxiety similarly by altering 5-HT1A receptor signaling.  Perhaps a greater dose (than 400 mg) would’ve attenuated anxiety before, during, and after the simulated public speaking task.  Furthermore, although Valium is an effective anxiolytic, it is clearly not optimal for public speaking as it increases sedation which may impair cognition and/or speech delivery.
Chronic stress can kill your quality of life, so stressed-out folks are always looking for proven ways to change this reality. Cannabis oil has the ability to both release pleasure hormones and relax the mind. It reduces stress and allows a calming and peaceful feeling to take over the body. Chemical components of cannabis, called cannabinoids, activate specific receptors found throughout the body to produce pharmacologic effects, particularly in the central nervous system and the immune system.
There were distinct changes in neural activation associated with the significant anxiolytic effects provided by CBD.  When compared to the placebo, administration of CBD significantly: increased ECD tracer uptake in the right posterior cingulate gyrus and decreased ECD tracer uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus.  Researchers concluded that reductions in social anxiety from CBD are related to modulation of neural activity in the limbic and paralimbic regions.
Hey Chris. Thanks for your inquiry. I completely understand why you would like to get off what you’re taking. I’d say a good place to start is with the serving size of the product you buy. A typical range for CBD is 10 – 20 mg of oral doses. CBD products are not very strain focused, so people typically just look at the mg of CBD when making a decision. Any other question, please free to ask away. Here to help 🙂
One of the strongest nutraceutical CBD oils is called Charlotte’s Web, with a 50mg dose. Charlotte’s Web is produced in Colorado by the Stanley Brothers, and named after Charlotte Figi, a girl who became famous in the US after her frequent seizures, brought on by the rare Dravet syndrome, were greatly reduced when she started taking CBD oil aged five. The company makes THC products too and is extremely successful, having just offered shares on the Canadian securities exchange, raising about $100m.
Looking back on it now, I can’t believe it’s never really occurred to me to try cannabis as a natural therapy – I have used marijuana kind of off and on a few times over the years, but never specifically to treat anxiety or any other condition. At most, I was what you might call a “social” pot user (and in fact, on several different occasions the weed that I smoked seemed to actually promote my anxiety and panic attacks – which I later learned was common with high THC strains).
Again, with all things, each person will react differently so you will have to know yourself well and maybe experiment with a few different concentrations to know what is right for you.  My friend used an equal ratio of CBD to THC and after just a week, his blood pressure was down, his bowel movements were much more regular, and it helped with his lactose intolerance.
Responsiveness to certain dosages may be subject to individual variation based on factors such as: body size, whether you take other medications, liver health, etc.  For this reason, it is necessary to always review the safety and efficacy of a hypothesized dosage with a medical professional.  Also understand that CBD is not guaranteed to reduce anxiety for every user, and therefore some individuals may derive zero benefit from any dose (even if extremely high).
I felt like many other users – afraid and nervous to take a dose of something that is supposed to take away my nervousness and anxiety. I use PureKana Vanilla 300mg. I’ve used it off and on for about a month. I started with 3-4 drops to get my body use to it and I noticed that the first night I tried it I ended up sitting on the couch watching t.v. not thinking about whether or not I was feeling ok – I just was. My bf asked how I was feeling and I was just feeling good – normal – calm. The next time, I took 4 – 6 drops but my anxiety overpowered the oil. I was going into a stressful work situation and even though I tried to attack the issue before I thought it would happen I ended up having an anxiety attack until I removed myself from the loud crowd and sat in nature with quietness. It was very discouraging at that point. I decided to give it a break and a week later I felt my stomach butterflies and ‘off’ feeling happening. I took 6 drops and sat outside where I was comfortable with a book and water. I ended up feeling fine and my anxiety just melted away without me realizing it. I think cbd oil is a great natural way to treat anxiety but go into it open-minded. It may work right away but sometimes the situation could outweigh the small dose and you just need more for a more stressful situation. I still believe in the power of the plant. It was put on this earth for a reason – to help!
In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act, which imposed a levy of $1 per ounce for medicinal use of cannabis and $100 per ounce for recreational use. This was opposed by physicians who were not required to pay a special tax for prescribing cannabis, use special order forms to obtain it and keep records detailing its professional use. The American Medical Association believed that evidence of cannabis’ harmful effects was limited and the act would prevent further research into its medicinal worth.
As we’ve outlined, Cannabidiol, or CBD, has receptors throughout your body, called the endocannabinoid system. Human beings can supplement this CBD system to aid and strengthen the immune system and other functions. Just like you may take vitamin c from an orange to supplement your health, CBD intake improves your endocannabinoid system and overall health. The increasing prevalence of CBD oils for the management and treatment of various illnesses has inspired cannabis breeders to propagate certain strains. The goal of manufacturers is to yield hemp plants with higher CBD to THC ratios to minimize, if not, eliminate, the psychoactive side effects caused by THC. According to research, the best source of high-quality CBD derives from organically grown cannabis with up to 20% CBD concentration by dry weight.
Canabidol™ Oral Capsules deliver 100% Cannabis Sativa L. from specifically bred industrial hemp plants containing high potency Cannabidiol. Each CBD capsule contains all the Cannabinoids, terpenoids, essential oils and all the other compounds of the cannabis plant. A packet of 30 capsules contains 15,000mg of Cannabis Sativa L. and 300mg of CBD (Cannabidiol) Each capsule contains 500mg of Cannabis Sativa L. and 10mg of the active ingredient CBD
“THC products are more for the psychoactive effect, which may not be for everyone,” the Steamboat Springs, Colorado, resident says. “CBD use is for more health-minded people.” Collins says CBD products “are a big part of my daily routine,” and credits them with boosting his energy levels, speeding his recovery from long trail runs, and improving his sleep.
I didn’t use the oil again until maybe about a week later, and I tried the next time around to really gauge when the effects started settling in. I was using the 300 mg bottle (30 mL), which I think is their lowest potency oil (they also had a 600 mg oil and a 1000 mg oil the last time I checked). It seemed to me that I noticed an obvious anxiety relief in less than an hour – maybe about 45 minutes, if I had to take a guess.
To this point, CBD oil has existed in a kind of liminal space— at once an illegal drug, a legal medication, and some kind of “dietary” supplement. It’s possible this could change in the coming years, however. GW Pharmaceuticals, a U.K.-based firm, has developed a “pure CBD” medication called Epidiolex that has shown promising test results. It is currently on a fast-track to receive FDA clearance. For some patients, Epidiolex could be a miracle cure. This summer, in Wired magazine, writer Fred Vogelstein chronicled his family’s own struggles to find an effective treatment for his son’s epilepsy—including experiments with hemp oil— and the immense hurdles they overcame to gain access to Epidiolex prior to its FDA approval. The drug could be for sale on pharmacy shelves in the near future, though exactly how near is hard to say.
May this letter find you and your loved ones happy and healthy for without you I would not be in such an improved state of physical health? It is not often I get to put pencil to paper for not only could I not concentrate due to opiate pharmaceuticals (couldn't express oneself due to lack of cognitive thinking) but the pain, inability to get comfortable due to lymphodemia and anxiety from stress (from lack of cash flow for food, bills, medicines plus the high expense of bandages & ointments) have prevented me from making contact but ....still after this prolonged period of time, I feel it necessary to write personally to mention just how dramatically you changed the world my two children and I live in. My sister Casey Lee Smith, arrived 6 months ago from the USA to run my household and it is through "Phoenix Tears" website she was able to make contact with you and learn all about the many wondrous benefits of medicinal Cannabis oil. When the treatment arrived, I was overwhelmed for I am a single Mother and your generosity brought tears to my eyes (even now it is hard to fight tears as I write) It has been rough to say the least. Feeling helpless, overly tired and frustrated by the lack of qualified physicians in my local town. I became depressed. My ex-husband felt he should prepare the kids for my untimely death. The location of my cancer spread throughout my left quadrant into my lymph and into the brain. I became bed ridden and lost hope. I will lose my house shortly but now i know it won't be my life. So, "THANK YOU" for the gracious gift and know you are loved! Sending love to you forever and always.
CBD may help reduces REM behavior disorder in people with Parkinson’s disease. REM behavior disorder is a condition that causes people to act out physically during dreaming and REM sleep. Typically, during REM, the body is largely paralyzed, a state known as REM atonia. This immobilization keeps sleepers from reacting physically to their dreams. In REM behavior disorder, this paralysis doesn’t occur, leaving people free to move—which can lead to disruptive sleep and to injuring themselves or their sleeping partners. Cannabis may also work to reduce pain and improve sleep quality in people with Parkinson’s disease.
“CBD coupled with stretching, icing, and foam rolling is a common treatment plan for tendonitis injuries about the knee, such as iliotibial band syndrome,” says Charles Bush-Joseph, M.D., a professor of orthopedics at Rush University Medical Center in Chicago. “Many patients like the fact that CBD is a natural substance. While specific research on the use of CBD in this instance is lacking, many believe that it helps prevent muscle and collagen breakdown.”
The definitions of hemp and marijuana can get pretty confusing, but for basic purposes, marijuana contains high levels of THC, and hemp contains low levels of THC. The ratios of CBD to THC in hemp oil can vary, depending on the product and the specific plant the oil was extracted from. CBD oil, a concentrated version of the cannabidiol compound, is typically derived from hemp but can be extracted from marijuana as well. CBD oil products on the market have varying levels of CBD and THC. Many have little to no THC, while some contain small amounts.
Dr. Will Cole, leading functional-medicine expert, consults people around the world via webcam at www.drwillcole.com and locally in Pittsburgh. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems.Dr. Cole was named one of the top 50 functional-medicine and integrative doctors in the nation and is the author of Ketotarian in which he melds the powerful benefits of the ketogenic and plant-based diets.
NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 200 retail locations across the country.
If you have been diagnosed with an anxiety disorder and/or are dealing with significant stress, have you tested CBD oil as an intervention?  Assuming you have tried CBD oil, share your experience in the comments section below.  To help others get a better understanding of your situation, include details such as: type of anxiety you have (e.g. social phobia), the dosage of CBD you took, and how effective it was for attenuating your anxiety (on a scale of 1 to 10).
With that said, I'm definitely intrigued enough by the subtle effects to continue taking the oil and possibly even to up the dosage to the recommended two full droppers of the 30mL bottle per day for a week or so. Plus, I take comfort in knowing that it's an all-natural treatment for anxiety that's responsibly grown on family farms in Colorado. Something that's safe, legal, requires no prescription, and makes me less anxious, less scatterbrained, and more focused? I'm definitely on board.
The second scenario involved anxiety associated with socializing, unknown strangers, a party going on, etc.  I also had been experiencing anxiety related to a health issue that’s been plaguing me for awhile and has yet to get corrected.  The health anxiety prompted me to run the second CBD experiment, and I went extra crazy with the dosing when the friend asked me to hang out.
Doesn’t affect cognition: A major drawback associated with anxiolytics is that many affect cognitive function. Sure it helps to take a pill and have less anxiety, but what if it compromises your cognitive abilities (e.g. critical thinking, problem solving, planning, etc.)?  Agents such as benzodiazepines are linked to memory problems and generally impair functionality despite reducing anxiety.  Research has highlighted CBD’s ability to reduce anxiety without impairing cognitive function.
Since then several other so-called endocannabinoids and their receptors have been discovered. Scientists have come to recognize that endocannabinoids interact with a specific neurological network—much the way that endorphins, serotonin, and dopamine do. Exercise, Mechoulam notes, has been shown to elevate endocannabinoid levels in the brain, and “this probably accounts for what jogging enthusiasts call runner’s high.” These compounds, he explains, apparently play an important role in such basic functions as memory, balance, movement, immune health, and neuroprotection.
These manufacturers comprehend CBD oils and moreover represent considerable authority in making a pure CBD crystal that is mainly for treating pressure and anxiety. Their CBD oils are produced in Vanilla and Mint flavours, while their organic products hit the spot. Pure Kana Natural CBD oil is an unflavored, dietary and nutritious supplement for expanded wellbeing and energy. Its mainly for unwinding and because of its mixes, it appears to have a quick impact. All items experience research facility testing to guarantee security and intensity and all their CBD oils are Non-psychoactive.
According to the case report, it was charted by the girl’s oncologist that the patient “suffers from terminal malignant disease. She has been treated to the limits of available therapy … no further active intervention will be undertaken.” She was then placed in a palliative home care and told to prepare for her disease to overwhelm her body. She was expected to suffer a stroke within the next two months.
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But it’s Guzmán’s brain tumor research that has captured headlines—and the interest of pharmaceutical companies. Through his years of research he has ascertained that a combination of THC, CBD, and temozolomide (a moderately successful conventional drug) works best in treating brain tumors in mice. A cocktail composed of these three compounds appears to attack brain cancer cells in multiple ways, preventing their spread but also triggering them, in effect, to commit suicide.
People claim that cannabis oil can be used to treat a wide range of conditions, though evidence to back up these claims is often lacking. For example, according to Medical News Today, people use cannabis oil for conditions ranging from pain to acne; some even claim the oil can cure diseases like Alzheimer's and cancer. (But again, there is no clinical evidence to support these claims.) 

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