In an initial experiment, the male Wistar rats received injections of CBD and were exposed to 60 minutes of restraint stress – with cardiovascular responses recorded.  In a second experiment designed to determine effects of CBD on the 5-HT1A receptor, researchers administered a 5-HT1A antagonist prior to the CBD.  Precisely 24 hours after CBD administration, the Wistar rats were tested in an elevated plus-maze to gauge anxiety.
In fact, CBD oil is growing popular among professional and collegiate athletes, who take it for muscle relaxation, recovery, pain relief, other benefits and medical conditions. Since it’s a safe, natural, and legal way to enhance your health and a viable alternative therapy, people young and old from all walks of life are trying CBD. Consult a physician before you begin taking CBD oil, and always purchase from a trusted source of American Hemp Oil.

Cannabidiol (CBD) is a phytocannabinoid constituent of Cannabis sativa that lacks the psychoactive effects of ∆9-tetrahydrocannabinol (THC). CBD has broad therapeutic properties across a range of neuropsychiatric disorders, stemming from diverse central nervous system actions [11, 12]. In recent years, CBD has attracted increasing interest as a potential anxiolytic treatment [13–15]. The purpose of this review is to assess evidence from current preclinical, clinical, and epidemiological studies pertaining to the potential risks and benefits of CBD as a treatment for anxiety disorders.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.
Depending on which hormone is stimulated, cannabis can boost or suppress appetite. For this reason, cannabis oil can help patients with eating disorders or be a natural way to treat obesity. This manipulation of the cannabinoid system is becoming popular, and more research is being done to determine its efficacy for patients with weight concerns. (6)
It is known that lack of sleep can interfere with certain aspects of cognitive functioning, such as attentional levels (Goel et al., 2009) and PVT, which has a high sensitivity to measure responses that require selective attention (Basner and Dinges, 2011). However, the results of the present study did not show any significant impairment in either the reaction time or number of errors measured by the PVT, suggesting that the attention levels of the volunteers were preserved in the morning after the sleep assessment, regardless of the administration of CBD or placebo. Not having administered the PVT test before CBD and placebo administration does not significantly affect the conclusions once the study does not intend to assess the effect of CBD on baseline vigilance (which would require comparison with baseline PVT results), but to rather evaluate if CBD may be safely administered to patients without affecting their vigilance state overall, such that the patients may safely conduct every-day tasks, like for example driving.
Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.
Runners pushing themselves daily might want to try more. Floyd’s of Leadville owner Bob Bell says that the company’s 50-milligram soft gels are its top seller. Talansky says his baseline is a 25-milligram gel, plus applying a strong topical cream three to five times a day if a specific body part is bothering him. He takes more on his hardest training days to speed recovery.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
CBD oil products can be somewhat expensive, which may be a barrier for individuals seeking treatment or relief from different conditions and disorders. Endoca is a notable exception as far as price-point is concerned. The brand offers two options for CBD oil: pure CBD; and RAW hemp oil that contains both CBD and cannabidiolic acid (CBDa). These oils are priced at $31 for 300mg oils and $129 for 1,500mg oils; both price-points are significantly below average.
Depending on which hormone is stimulated, cannabis can boost or suppress appetite. For this reason, cannabis oil can help patients with eating disorders or be a natural way to treat obesity. This manipulation of the cannabinoid system is becoming popular, and more research is being done to determine its efficacy for patients with weight concerns. (6)
Blake Pearson, founder of GreenlyMed and a practicing doctor in Ontario, Canada, specializes in cannabinoid medicine and said he has personally seen patients who have lowered their intake of prescription medications or reduced the negative side effects of taking other medications. However, Pearson would like to see more robust research, including random controlled trials.

A geneticist, Kane studies cannabis from a unique perspective—he probes its DNA. He’s an affable, outdoorsy guy with a bright face and eyes that wander and dart inquisitively when he talks. He has studied chocolate and for many years the sunflower, eventually mapping its genome, a sequence of more than three and a half billion nucleotides. Now he’s moved on to marijuana. Though its sequence is much shorter, roughly 800 million nucleotides, he considers it a far more intriguing plant.

All exposure to restraint stress resulted in increased blood pressure and heart rate, thereby significantly increasing anxiety in the elevated plus-maze 24 hour.  However, administration of CBD alleviated the anxiety associated with the elevated plus-maze.  Prior administration of the 5-HT1A antagonist inhibited the therapeutic effects of the cannabidiol.

One thing that I really really liked though, was that the effects seemed to last a long time. I have only taken the oil on four separate occasions now, and each time it’s seemed to last like 6-8 hours (or at least all evening). This makes sense too, because after doing a little reading up I found that the sublingual tinctures are much longer-lasting than CBD vape oils or e-juices.

Sourcing: In addition to formatting of CBD, the sourcing may make a difference in terms of quality. The modality of CBD extraction used to isolate the CBD may affect its quality and efficacy.  Examples of some common extraction techniques include: carrier-oil extraction, CO2 extraction, and alcohol extraction.  Implications of sourcing and extraction techniques should be considered by researchers.

When formulating a CBD regimen for a specific disease or illness (like sleep disorders), it’s important to understand that CBD should be used regularly for maximum relief. It’s also helpful to understand whether another condition like anxiety, PTSD or pain is actually the root cause of your sleep disorder. The recommended regimen will also vary slightly based on the type of sleeping disorder you have – i.e. those suffering from insomnia will need to consume their CBD at a different time of day than those suffering from excessive daytime fatigue.
People with specific phobias experinence strong, irrational fears of certain objects, places, or situations (fear of snakes, flying, big spaces, small spaces, etc.). These phobias can disrupt daily routines and limit a persons abilities to function properly. Some phobias develop in childhood, while others in adolescence or early adulthood. 19 million, 8.7% of the US population suffer from specific phobias. Women are twice as likely to be affected as men.
In terms of recent scientific investigations on the topic, in 2011 a group of researchers conducted a study that revolutionized the thoughts about CBD and anxiety. They took 10 people with social anxiety who had never had any treatment for this disorder and divided them into two groups. One group was given 400mg of CBD and the other a placebo. The results showed that those who had received the CBD oil had successfully improved their anxiety symptoms compared to the placebo.
A study published in 1993 by Zuardi et al. attempted to elucidate the effects of ipsapirone and cannabidiol among humans exposed to an experimental anxiety task.  For the study, researchers recruited 40 healthy volunteers that were assigned to a simulated public speaking (SPS) test – designed to mimic the effects of public speaking.  The 40 participants were divided into 4 groups of 10 – each of which was assigned randomly to receive: CBD (300 mg), Valium (10 mg), ipsapirone (5 mg), or a placebo.
Are you willing to share what you're anxiety is about? I had panic and anxiety attacks for years and used Ativan and later Lorazepam for them, especially when I had to fly in planes. About 6 years ago I started taking Citalopram antidepressant, and all my anxiety/panic attacks went away. I only had it again recently during my withdrawal process. I know my relief from anxiety is from the Citalopram. I even did 7 zip lines in Costa Rica a little over a year ago. My flights there, to Panama and back were anxiety free. That has been so incredible for me! I love traveling now.
However, the 2014 federal farm bill allowed for “research” cultivation and marketing of industrial hemp if those activities aren’t in violation of state laws. Only four states—Idaho, North Dakota, Nebraska, and Kansas—have strict no-CBD laws. Since 2014, there has been little to no federal enforcement against commercial hemp products. The upshot: Functionally, hemp-derived CBD products are safe for interstate commerce.
Adenosine 2A receptor: Administration of CBD is thought to act upon the adenosine 2A receptor site, possibly contributing to its anxiolytic and anti-inflammatory effects.  Adenosine receptors are known to influence cardiovascular processes (cardiac rhythm, circulation), immune function, sleep, pain regulation, and blood flow.  The adenosine 2A receptor interacts with G proteins to alter cAMP (cyclic adenosine monophosphate).  Dysfunction of the adenosine 2A receptor may disrupt neurotransmission of glutamate and dopamine, and simultaneously cause inflammation, neurodegeneration, and possibly anxiety.
My son takes it for adhd. I have a friends child who takes it for autism and lots of testimonials for both issues on my testimonial page. Feel free to reach out to me. I suggest first finding a oil that is full soectrum and ALL ORGANIC! no solvents no chemicals no fillers co2 extraction method. I am in the cannabis industry and this has completely changed my son’s life and others. As well as my own for anxiety.

Cannabidiol’s anti-anxiety (Zuardi et al., 1993, 2017; Crippa et al., 2009; Bergamaschi et al., 2011b) and antidepressant (Saito et al., 2010; Zanelati et al., 2010) potential seems to differ from other drugs with effects on the central nervous system, since we found no alterations in sleep architecture. Additionally, studies on the anxiolytic, antipsychotic and antiparkinson effects of CBD described no sedation or drowsiness side effects in their volunteers (Zuardi et al., 1993; Crippa et al., 2004; Fusar-Poli et al., 2009; Chagas et al., 2014a). These findings complement the literature on the few significant side effects resulting from the administration of CBD to humans in a wide range of doses, administered chronically or acutely (Bergamaschi et al., 2011b; Kerstin and Grotenhermen, 2017). It seems, therefore, that CBD has an adequate safety profile with good tolerability and does not affect psychomotricity or cognition (Hayakawa et al., 2007; Crippa et al., 2010; Bergamaschi et al., 2011b; Kerstin and Grotenhermen, 2017). This is particularly important in Parkinson’s disease, where motor and cognitive symptoms play a central role.


THC (Tetrahydrocannabinol) Cannabis oil and Cannabidiol (also called CBD) have similarities but some important differences for users. Both cannabinoids, chemical compounds that can be found in all cannabis plants, including hemp and marijuana. Cannabinoids are the substances secreted by the flowers of the cannabis plant and contain natural medicinal properties, offering relief from conditions including anxiety, pain, nausea, and inflammation. There are plant-based cannabinoids and also phytocannabinoids, both with a variety of health benefits.
Third-party testing: Once a CBD oil is manufactured, CBD oil companies will often submit their products for third-party tests, which are conducted by non-company personnel to ensure the product is safe for public consumption and meets quality standards.CBD oils should always be accompanied with information about third-party tests; best practice is to avoid oils that do not supply these details.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.

“These studies mainly point to CBD’s ability to interact with ... serotonin receptors and GABA receptors in the brain,” she explained. “Serotonin plays an important role in mood and anxiety, and GABA is known as the main ‘inhibitory’ neurotransmitter, meaning it calms excess activity in the brain and promotes relaxation. GABA receptors are the target of benzodiazepines, which are a class of anti-anxiety drugs.”
In regard to their products, Elixinol offers a variety of CBD oils, tinctures, balms, and if you want to treat your pet, they’ve even got pet relief edibles. For those of you who don’t mind taking capsules, they provide a 450mg CBD Hemp oil capsule which some people have said helps assists specific conditions, but their tinctures are more popular and for many are known to do the trick.
In this article, we ranked the best CBD oils for sleep according to quality, the company’s customer support, the extraction process, and of course, personal use. All five CBD oils have been amazing for many individuals in terms of sleep, insomnia or related issues, and as we tend not to play favorites, we can’t recommend just one. Instead, we’ll go ahead and tell you that the two CBD oil companies that were voted by our team as the best of 2018 are:
Whatever the case, if you suffer from anxiety, panic attacks, depression, or insomnia, I would absolutely recommend you give a quality CBD oil a shot. I was certainly not quick to buy into the whole hype machine (I know that the cannabis industry is pretty crazy right now), but I can say as a first time user that it legitimately did work, and it caused absolutely no high or side effects whatsoever.
But all was not well. Harper has continued to experience health issues related to her condition. And seven months after starting to use CBD oil, Harper’s seizures returned— although not as frequently as before. Penny uses eleven iPhone reminders to keep track of Harper’s daily regimen of medications and food, and she records all of Harper’s seizures in a thickly bound black book. But as her parents continue to closely monitor Harper’s health and adjust her medications accordingly, her doctors are tightly limited in the advice they can offer when it comes to CBD oil. “There’s no research on this product, so they don’t say it’s good or bad. They just say, ‘Don’t stop giving it,’” Penny told me.
As noted, CBD has been found to have a bell-shaped response curve, with higher doses being ineffective. This may reflect activation of TRPV1 receptors at higher dose, as blockade of TRPV1 receptors in the DPAG rendered a previously ineffective high dose of CBD as anxiolytic in the EPM [66]. Given TRPV1 receptors have anxiogenic effects, this may indicate that at higher doses, CBD’s interaction with TRPV1 receptors to some extent impedes anxiolytic actions, although was notably not sufficient to produce anxiogenic effects.
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One of the most common reasons given by people who use cannabis daily is that they want to improve their sleep. Though, the study findings show occasional use doesn’t disrupt sleep, heavy use or daily use can be associated with sleep difficulties. The effect of daily use on sleep patterns seems to mimic that of alcohol use, in the sense that daily use worsens sleep while intermittent use improves sleep continuity. Neurologist and somnologist, Dr Hans Hamburger explains,
@lalyfa In 2010 I went off a cocktail of psychotropics including antidepressants, antianxiety and antipsychotics cold turkey. The meds were wrong for me and the withdrawal was severe and I rarely slept, had RLS, neuropathy and cranky beyond words. Some of these meds took 9+ months to clear my system. Be sure to follow doctor's advice. I did not have a doctor at the time and would not go to the ER knowing it would have resulted in more abuse. Not an intelligent thing to do and not sorry I made the choice even though the experience was horrific and would not reccomend anyone go this route. As to how long the withdrawal lasts the best thing is to discuss this with a pharmacist as this is where their training is and they understand much better and be of help. Wishing you the best.
By popular demand, we have also begun to carry several, high quality CBD pet products as well. For general purpose applications, we carry several, tasty tincture and oral spray options that are highly effective. Likewise, Pharma CBD capsules provide CBD purity via capsular ingestion. In addition, we have partnered with Therabis, the quality CBD maker of “Stop the Itch” and “Calm and Quiet”, the pet lovers’ ultimate go-to’s. Find these products by browsing our exclusive online inventory.
Hash oils seized in the 1970s had a THC contents ranging from 10 to 30%. The oil available on the U.S. West Coast in 1974 averaged about 15% THC.[2] Samples seized across the United States by the Drug Enforcement Administration over an 18-year period (1980–1997) showed that THC content in hashish and hashish oil averaging 12.9% and 17.4%, respectively, did not show an increase over time.[4] The highest THC concentrations measured were 52.9% in hashish and 47.0% in hash oil.[5] Hash oils in use in the 2010s had THC concentrations as high as 90%[6][7] and other products achieving higher concentrations [8]
Overall, preclinical evidence supports systemic CBD as an acute treatment of GAD, SAD, PD, OCD, and PTSD, and suggests that CBD has the advantage of not producing anxiogenic effects at higher dose, as distinct from other agents that enhance CB1R activation. In particular, results show potential for the treatment of multiple PTSD symptom domains, including reducing arousal and avoidance, preventing the long-term adverse effects of stress, as well as enhancing the extinction and blocking the reconsolidation of persistent fear memories.
In terms of recent scientific investigations on the topic, in 2011 a group of researchers conducted a study that revolutionized the thoughts about CBD and anxiety. They took 10 people with social anxiety who had never had any treatment for this disorder and divided them into two groups. One group was given 400mg of CBD and the other a placebo. The results showed that those who had received the CBD oil had successfully improved their anxiety symptoms compared to the placebo.

Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.


Hash oil or cannabis oil is an oleoresin obtained by the extraction of cannabis or hashish. It is a concentrated form of the plant containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids. There are a variety of extraction methods, but most involve a solvent such as butane or ethanol. Hash oil is usually consumed by smoking, vaporizing or eating but sometimes other methods are employed. Hash oil is sometimes sold in cartridges to be used with pen vaporizers.
My dad has severe advanced stage Dementia. Will CBD oil help him at this point? He is now refusing to eat any solid food, but will accept most drinks.In addition, he has lost a great deal of weight even though they're giving him Mega Shakes containing a full meals worth of proteins, etc. He gets at least 4 of these a day..some which he refuses. Is his Dementia too far gone for CBD oils to help him?
Like Elixinol, CBD Essence has been around for quite a few years and they definitely know a thing or two about hemp oil. The owner Don has actually been around the pharmaceutical industry for some years, and therefore knows how to deliver a quality and effective product. All of their oils are created using CO2 extraction methods, which have been known to be safer and more effective than solvent-based extraction. They avoid CBD isolates, and they always disclose lab test results to ensure there are no heavy metals or contaminants in the oil.
Currently, studies suggest that CBD attaches to the cannabinoid receptors, CB1 and CB2, within the body, which works to maintain homeostasis in the body. CB2 receptors were found in much higher amounts in the joints of arthritis sufferers and when CBD was introduced into the body, it was found to interact with these receptors, promoting analgesia in the affected area. It also suggested that it was unlikely that CBD users would build up an eventual resistance, and so could be used without gradual reuptake.

If you are suffering from pain which is preventing you from having a good nights sleep, then CBD Essence may be the solution. CBD essence has quite a unique extraction process which involves state-of-the-art technology and high-grade hemp that goes through some of the most rigorous testing. This allows them to produce a product that is rich in hemp extract, and contains several key ingredients found in the Cannabis plant.

The definitions of hemp and marijuana can get pretty confusing, but for basic purposes, marijuana contains high levels of THC, and hemp contains low levels of THC. The ratios of CBD to THC in hemp oil can vary, depending on the product and the specific plant the oil was extracted from. CBD oil, a concentrated version of the cannabidiol compound, is typically derived from hemp but can be extracted from marijuana as well. CBD oil products on the market have varying levels of CBD and THC. Many have little to no THC, while some contain small amounts.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!

While research into CBD effects is still relatively new, studies have found that cannabidiol may reduce pain by influencing compounds in the body’s endocannabinoid system (ECS). More specifically, CBD prevents the body from breaking down the compound anandamide, which is associated with pain regulation. A higher concentration of anandamide in the bloodstream has been linked to significant pain reduction.


CBD can be taken in a few ways. Oil is probably the most popular, but it can also be taken in capsule form, or even as a chocolate or gummy. After a week of taking CBD in oil form every night, it was clear I’d stumbled across something kind of remarkable. I often slept well the first few nights of trying something new before it stopped working its magic, which I partially attribute to the placebo effect. With CBD, however, the good nights of sleep kept on coming.
Bioavailability: The bioavailability of orally-administered CBD is considered extremely low (around 6%). If you smoke cannabidiol, the bioavailability increases to over 30% and if you utilize an intranasal preparation, bioavailability may reach nearly 50%.  However, since many people are using oral preparations of CBD, the bioavailability is low and will require a high dose.
Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effects, and CBD, which lacks these psychoactive effects. Preclinical and clinical studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties (see [11, 12, 16–19] for reviews). A review of potential side effects in humans found that CBD was well tolerated across a wide dose range, up to 1500 mg/day (orally), with no reported psychomotor slowing, negative mood effects, or vital sign abnormalities noted [20].
As it turns out, healthy sleep-wake cycles are extremely dependent on our state of “alertness” during the day. If you are a victim of insomnia, for example, you (along with millions of other individuals) are likely drowsy, fatigued, and generally “out-of-sorts” during the afternoon. As you might imagine, this wreaks havoc on your sleep-wake cycle as it makes it nearly impossible to enter and maintain the non-REM sleep that you need at night.

Hey Cynthia. Thanks for your inquiry. No, this doesn’t hold true for CBD. The best thing to do is to start low and slowly increase the dose gradually, only if needed. You want to find your personal sweet spot dose with CBD. One easy way to do that is to start out with the serving size listed on the bottle and go from there. Let me know if you have more questions and I will do my best to help 🙂


At first, I was wary. Although I live in Los Angeles, where it seems like there’s a medical marijuana depot on every corner, I’m not one for doing drugs (legal or otherwise). I mean, I don’t even take Advil when I get a headache!  But despite the fact that CBD oil is made from hemp, it doesn’t contain THC. THC is the compound responsible for the “high” that comes with ingesting marijuana. In fact, scientific reviews have proven that CBD “does not interfere with several psychomotor and psychological functions,” and is safe to ingest without any side effects. Let me repeat: YOU WILL NOT GET HIGH FROM CBD!
This is a topic I am asked about all the time, and have been for years: how does cannabis help sleep and health? I’ve heard that the number-two reason why people smoke or use cannabis is for sleep. Considering the recent passing of the recreational use of cannabis in California and other several states I think it is high time (pun intended!) to look at understanding CBD, one of the most active ingredients in medical cannabis.
A sketchy outline of the cannabis genome already exists, but it’s highly fragmented, scattered into about 60,000 pieces. Kane’s ambitious goal, which will take many years to achieve, is to assemble those fragments in the right order. “The analogy I use is, we have 60,000 pages of what promises to be an excellent book, but they’re strewn all over the floor,” he says. “We have no idea yet how those pages fit together to make a good story.”
Cannabis Oil: Cannabis oil is typically made from marijuana with a high THC percentage. Therefore, it must be purchased in an area where marijuana is legal or can be obtained with a prescription. The amounts of compounds, including CBD and THC, will drastically vary from product to product. Commercially produced cannabis oils will have more controlled concentrations of CBD and THC for medical purposes.

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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.

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